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| | N-methyl-N'-(azide-PEG3)-Cy3 Basic information |
| | N-methyl-N'-(azide-PEG3)-Cy3 Chemical Properties |
| solubility | Soluble in DMSO, DMF, DCM, low solubility in water |
| | N-methyl-N'-(azide-PEG3)-Cy3 Usage And Synthesis |
| Description | N-methyl-N'-(azide-PEG3)-Cy3 is a PEG linker containing cyanine dye with excitation/emmission maximum 555/570 nm as well as an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media. | | Uses | N-methyl-N'-(azide-PEG3)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-methyl-N'-(azide-PEG3)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-methyl-N'-(azide-PEG3)-Cy3 Preparation Products And Raw materials |
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