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Potassium thioacetate

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Potassium thioacetate Basic information
Product Name:Potassium thioacetate
Synonyms:Acetic acid, thio-, potassium salt;Potassium thioethanoate;Potassium thioacetate,98%;Kaliumthioacetat;Potassium thioaccetate;Potasium thioacetate;Potassium thioacetat;PotassiuM thioacetate, 98% 25GR
CAS:10387-40-3
MF:C2H4OS.K
MW:115.22
EINECS:233-848-7
Product Categories:Pharmaceutical intermediates;10387-40-3
Mol File:10387-40-3.mol
Potassium thioacetate Structure
Potassium thioacetate Chemical Properties
Melting point 173-176 °C (lit.)
density 1.58 g/cm3
bulk density500kg/m3
storage temp. Inert atmosphere,Room Temperature
solubility soluble
pka3.6
form Crystalline Powder, Crystals or Chunks
color White to light brown
Water Solubility soluble
Sensitive Air Sensitive & Hygroscopic
Hydrolytic Sensitivity4: no reaction with water under neutral conditions
BRN 3595448
InChIInChI=1S/C2H4OS.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
InChIKeyAFNBMGLGYSGFEZ-UHFFFAOYSA-M
SMILESC([S-])(=O)C.[K+]
CAS DataBase Reference10387-40-3(CAS DataBase Reference)
EPA Substance Registry SystemEthanethioic acid, potassium salt (10387-40-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
RIDADR UN 3335
WGK Germany 3
3-9-13-23
TSCA TSCA listed
HazardClass 9
HS Code 29309070
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
Mercaptoacetic acid potassium salt English
ALFA English
Potassium thioacetate Usage And Synthesis
Chemical Propertieswhite to light brown crystalline powder, crystals
UsesPotassium Thioacetate is the potassium salt of Thioacetic Acid, a commonly used reagent in organic synthesis for the introduction of thiol groups in molecules.
UsesPotassium thioacetate is used for palladium mediated coupling with aryl halides and triflates leading to S-arylthioacetates and derivatives. It is also used as a reagent in the conversion of halides to thiols.
ApplicationPotassium thioacetate is an organosulfur compound and a salt with the formula CH3COS−K+. This white, water-soluble solid is used as a reagent for preparing thioacetate esters and other derivatives . It acts as a sulfur source in the synthesis of sulfur-containing organic compounds for the synthesis of heterocycles, polymers, transition-metal ligands, nanoparticles, bioactive compounds and macromolecular inclusion complexes. It is also used for palladium mediated coupling with aryl halides and triflates leading to S-arylthioacetates and derivatives and it is also used as a reagent in the conversion of halides to thiols.
ReactionsThioacetate is also a class of sulfur-containing nucleophiles, of which potassium thioacetate is the most widely used reagent. Potassium thioacetate reacts with organic halides to form thioesters, which are often used as thiol-protecting groups.In the classical reaction, potassium thioacetate replaces the bromine atom to form a thiol in which the thioester formed in the first step is subjected to a nucleophilic addition elimination reaction to obtain a thiol via hydrolysis, alcoholysis or ammonolysis. Unlike the thiol formation from bromine and thiourea, this method is not strictly limited to polystyrenes. It can also be extended to poly(meth)acrylate systems. It is important that there is no observation of ester hydrolysis during the process.
Tag:Potassium thioacetate(10387-40-3) Related Product Information
Sodium thiosulfate Thioacetic acid Thioglycolic acid Tetradecylthioacetic acid Losartan potassium Potassium bromate POTASSIUM THIOGLYCOLATE Potassium Citrate S-METHYL THIOACETATE Thioacetamide Potassium iodide Potassium Acetate 2-Thiobarbituric acid Potassium sorbate Ethanethioic acid S-ethyl ester Potassium persulfate Potassium chloride Potassium thiosulfate

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