MK-0249

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MK-0249 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:MK-0249
CAS:862309-06-6
Purity:98.00% Package:1 mg；10 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Email: sales@medchemexpress.cn
Products Intro: Product Name:MK-0249
CAS:862309-06-6
Purity:>98% Package:5800RMB/1mg
Company Name: Beijing xinyanhui pharmaceutical research and development co., LTD  
Tel: 13969155946
Email: 1461866103@qq.com
Products Intro: CAS:862309-06-6
Purity:99% HPLC Package:5KG;1KG；500G;100G;50G
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:MK-0249
CAS:862309-06-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Products Intro: Product Name:MK-0249
CAS:862309-06-6
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
MK-0249 Basic information
Product Name:MK-0249
Synonyms:MK-0249;4(3H)-Quinazolinone, 2-methyl-3-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-5-(trifluoromethyl)-;MK0249,MK 0249
CAS:862309-06-6
MF:C23H24F3N3O2
MW:431.45
EINECS:
Product Categories:
Mol File:862309-06-6.mol
MK-0249 Structure
MK-0249 Chemical Properties
Boiling point 572.5±60.0 °C(Predicted)
density 1.30±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka10.19±0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
MK-0249 Usage And Synthesis
UsesMK-0249 (Compound 1) is a potent, selective and orally active histamine H3 receptor antagonist, with an IC50 of 1.7 nM for human H3[1].
IC 50human H3 receptor: 1.7 nM (IC50); rhesus H3 receptor: 4.3 nM (Ki); human H3 receptor: 6.8 nM (Ki); rat H3 receptor: 33 nM (Ki)
References[1] Nagase T, et al. Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem. 2008 Aug 14;51(15):4780-9. DOI:10.1021/jm8003834
MK-0249 Preparation Products And Raw materials
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