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AZD-4694 manufacturers
- AZD4694
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- $1270.00
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2026-05-11
- CAS:1054629-49-0
- Purity:
- Supply Ability: 10g
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| | AZD-4694 Basic information |
| Product Name: | AZD-4694 | | Synonyms: | AZD-4694;5-Benzofuranol, 2-[2-fluoro-6-(methylamino)-3-pyridinyl]-;Flutafuranol;NAV 4694;NAV-4694;NAV4694 | | CAS: | 1054629-49-0 | | MF: | C14H11FN2O2 | | MW: | 258.25 | | EINECS: | | | Product Categories: | | | Mol File: | 1054629-49-0.mol |  |
| | AZD-4694 Chemical Properties |
| Boiling point | 457.2±45.0 °C(Predicted) | | density | 1.381±0.06 g/cm3(Predicted) | | pka | 8.86±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | AZD-4694 Usage And Synthesis |
| Uses | AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM)[1]. | | in vivo | Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue[1].
AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients[1]. | Animal Model: | Male Sprague–Dawley rats (275-300 g)[1] | | Dosage: | 4 mL/kg | | Administration: | I.v. | | Result: | Inhibited [3H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.
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| | References | [1] Juréus A, Swahn BM, Sandell J, et al. Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand. J Neurochem. 2010;114(3):784-794. DOI:10.1111/j.1471-4159.2010.06812.x |
| | AZD-4694 Preparation Products And Raw materials |
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