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5'-Azido-5'-deoxy-5-methyluridine manufacturers
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| | 5'-Azido-5'-deoxy-5-methyluridine Basic information |
| | 5'-Azido-5'-deoxy-5-methyluridine Chemical Properties |
| | 5'-Azido-5'-deoxy-5-methyluridine Usage And Synthesis |
| Uses | 5’-Azido-5’-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
| | 5'-Azido-5'-deoxy-5-methyluridine Preparation Products And Raw materials |
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