205654-37-1
| 中文名称 | 205654-37-1 |
|---|---|
| 中文同义词 | 化合物 T10844;化合物 CMI-392 |
| 英文名称 | Urea, N'-[[2-[2-[(4-chlorophenyl)thio]ethoxy]-3-methoxy-5-[(2S,5S)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]methyl]-N-hydroxy-N-methyl- |
| 英文同义词 | Urea, N'-[[2-[2-[(4-chlorophenyl)thio]ethoxy]-3-methoxy-5-[(2S,5S)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]methyl]-N-hydroxy-N-methyl-;CMI 392,CMI392 |
| CAS号 | 205654-37-1 |
| 分子式 | C31H37ClN2O8S |
| 分子量 | 633.15 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 205654-37-1.mol |
| 结构式 |  |
205654-37-1 性质
| 密度 | 1.35±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.82±0.50(Predicted) |
CMI-392是一种双重 5-lipoxygenese 抑制剂和血小板活化因子 (PAF) 受体拮抗剂，IC50 值分别为100和10 nM。
|
5-LO 100 nM (IC 50 ) |
PAF 10 nM (IC 50 ) |
Topical treatment of CMI-392 in the acute and chronic TPA models result in a significant decrease of ear weight, inflammatory cell infiltration, and histological examination. The ED 50 for PAF-induced mouse hemoconcentration and arachidonic acid-induced mouse ear edema are 2.2 and 1.8 mg/kg, respectively.