PC Alkyne-PEG4-NHS carbonate ester manufacturers
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| | PC Alkyne-PEG4-NHS carbonate ester Basic information |
| Product Name: | PC Alkyne-PEG4-NHS carbonate ester | | Synonyms: | PC Alkyne-PEG4-NHS carbonate ester;PC Alkyne-PEG4-NHS ester;Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-azaeicos-19-yn-1-yl)oxy]phenyl]ethyl ester;2,5-Dioxopyrrolidin-1-yl (1-(5-methoxy-2-nitro-4-((17-oxo-4,7,10,13-tetraoxa-16-azaicos-1-yn-20-yl)oxy)phenyl)ethyl) carbonate | | CAS: | 1802907-98-7 | | MF: | C29H39N3O14 | | MW: | 653.63 | | EINECS: | | | Product Categories: | | | Mol File: | 1802907-98-7.mol |  |
| | PC Alkyne-PEG4-NHS carbonate ester Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. -20°C | | form | Viscous Liquid | | pka | 15.38±0.46(Predicted) | | color | Light yellow to yellow |
| | PC Alkyne-PEG4-NHS carbonate ester Usage And Synthesis |
| Description | PC Alkyne-PEG4-NHS carbonate ester is a photocleavable linker with an alkyne and NHS carbonate ester end group. The NHS ester can react with primary amines. The alkyne can participate in copper-catalyzed Click Chemistry reactions with azide moieties. | | Uses | PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | PC Alkyne-PEG4-NHS carbonate ester Preparation Products And Raw materials |
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