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| | Masupirdine mesylate Basic information |
| | Masupirdine mesylate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | Pale purple to purple |
| | Masupirdine mesylate Usage And Synthesis |
| Uses | Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1]. | | IC 50 | 5-HT6 Receptor: 2.04 nM (Ki) | | References | [1] Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Po DOI:10.1021/acs.jmedchem.6b01662 |
| | Masupirdine mesylate Preparation Products And Raw materials |
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