VU0469650 manufacturers
- VU 0469650
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- $37.00
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2026-07-14
- CAS:1443748-47-7
- Purity: 98.03%
- Supply Ability: 10g
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| | VU0469650 Basic information |
| Product Name: | VU0469650 | | Synonyms: | 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride;VU 0469650 hydrochloride;3-[(3R)-3-METHYL-4-[(4-METHYLADAMANTAN-1-YL)CARBONYL]PIPERAZIN-1-YL]PYRIDINE-2-CARBONITRILE;VU0469650;CID73755207;2-Pyridinecarbonitrile, 3-[(3R)-3-methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-;VU 0469650 HCl;VU0469650|||VU 0469650|||VU-0469650|||VU 0469650 HCl | | CAS: | 1443748-47-7 | | MF: | C22H28N4O | | MW: | 364.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1443748-47-7.mol |  |
| | VU0469650 Chemical Properties |
| Boiling point | 584.7±50.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mM,Ethanol: 50 mM | | pka | 1.42±0.12(Predicted) | | form | Solid | | color | Off-white to light yellow | | Optical Rotation | [α]/D -41 to -51°, c =1 in methanol |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | VU0469650 Usage And Synthesis |
| Uses | VU 0469650 Hydrochloride is potent and selective negative allosteric modulators of metabotropic glutamate receptor 1 (mGlu1). | | Biological Activity | VU0469650 is a brain-penetrant, potent and selective metabotropic glutamate receptor 1 (mGlu1) negative allosteric modulator (NAM). VU0469650 selectively inhibits glu-induced Ca2+ influx in human mGluR1-expressing HEK 293A (EC50 = 99 nM with [Glu] = EC20 for 1.9 min, then EC100 for 1.7 min; inactive against cells expressing human mGlu2-8 at 10 μM) with no affinity toward a panel of 68 clinically relevant GPCRs, ion channels, kinases, and transporters. Prior administration of VU0469650 in mice in vivo (60 mg/kg i.p.) modulates the antipsychotic activity of M4 muscarinic receptor PAM VU0467154 and th at of the M1/M4 agonist xanomeline. | | in vivo | VU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour[1].
VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples[1]. | | IC 50 | mGluR 1: 99 nM (IC50) | | storage | Store at +4°C |
| | VU0469650 Preparation Products And Raw materials |
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