- NIPECOTAMIDE
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- $1.00 / 1KG
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2025-12-12
- CAS:4138-26-5
- Min. Order: 1KG
- Purity: 99%+
- Supply Ability: 1076KG
- NIPECOTAMIDE
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- $0.00 / 25KG
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2025-12-01
- CAS:4138-26-5
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
- NIPECOTAMIDE
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- $7.00 / 1KG
-
2019-09-02
- CAS: 4138-26-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: JD 533
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| | NIPECOTAMIDE Basic information |
| | NIPECOTAMIDE Chemical Properties |
| Melting point | 103-106 °C(lit.) | | Boiling point | 237.61°C (rough estimate) | | density | 1.0754 (rough estimate) | | refractive index | 1.4880 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Crystalline Powder | | pka | 16.50±0.20(Predicted) | | color | Yellow | | InChI | InChI=1S/C6H12N2O/c7-6(9)5-2-1-3-8-4-5/h5,8H,1-4H2,(H2,7,9) | | InChIKey | BVOCPVIXARZNQN-UHFFFAOYSA-N | | SMILES | N1CCCC(C(N)=O)C1 | | CAS DataBase Reference | 4138-26-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | NIPECOTAMIDE Usage And Synthesis |
| Chemical Properties | YELLOW CRYSTALLINE POWDER | | Uses | Reactant for synthesis of:• ;DPP-4 inhibitors1• ;IKKβ inhibitors2• ;Spiroimidazolidinone NPC1L1 inhibitors3• ;Sulfamides4• ;Phosphodiesterase 5 inhibtors5• ;Anti-HIV agents6 | | Uses | Nipecotamide, is a budiling blcok used in the sythnesis of various compounds, such as DPP-4 inhibitors, IKKβ inhibitors, piroimidazolidinone NPC1L1 inhibitors, and Anti-HIV agents. | | Definition | ChEBI: The amide resulting from the formal condensation of nipecotic acid with ammonia. | | Synthesis | 122.12 g (1.00 mol) of nicotinamide was dissolved in 500 mL of 2-propanol. To this solution was added 14.4 g of 10% palladium-carbon catalyst, followed by stirring the reaction for 4 hours at 75 °C under 0.5 MPa hydrogen pressure. Upon completion of the reaction, the palladium-carbon catalyst was removed by filtration and the filter cake was washed with 100 mL of 2-propanol. The filtrate and washings were combined and concentrated to give 126.08 g of racemic 3-piperidinecarboxamide white crystals in 98.4% yield. The structure of the product was confirmed by NMR characterization. | | References | [1] Patent: US2012/123128, 2012, A1. Location in patent: Page/Page column 3
[2] Synlett, 2006, # 9, p. 1440 - 1442
[3] Chemistry - A European Journal, 2009, vol. 15, # 28, p. 6953 - 6963
[4] Synlett, 2008, # 8, p. 1125 - 1128
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 1680 |
| | NIPECOTAMIDE Preparation Products And Raw materials |
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