N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide

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N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide manufacturers

  • GNE-9822
  • GNE-9822 pictures
  • $1960.00
  • 2026-05-18
  • CAS:1557232-32-2
  • Purity: 99.90%
  • Supply Ability: 10g
N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide Basic information
Product Name:N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide
Synonyms:N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide;1H-Indazole-3-carboxamide, N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl]-4,5,6,7-tetrahydro-6,6-dimethyl-;N-{1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide;GNE-9822
CAS:1557232-32-2
MF:C24H32N6O
MW:420.55
EINECS:
Product Categories:
Mol File:1557232-32-2.mol
N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide Structure
N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide Chemical Properties
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide Usage And Synthesis
DescriptionGNE-9822 is a potent and selective ITK inhibitor. GNE-9822 shows good ADME properties in preclinical species. Interleukin-2 inducible T-cell kinase (ITK), a member of the Tec family of tyrosine kinases, plays a major role in T-cell signaling downstream of the T-cell receptor (TCR), and considerable efforts have been directed toward discovery of ITK-selective inhibitors as potential treatments of inflammatory disorders such as asthma.
UsesGNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM, and an EC50 value of 354.5 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma[1][2].
in vivo

GNE-9822 (compound 28; po and iv; 1 and 5 mg/kg) has good bioavailability and halflives observed in mouse and rats[1].

Animal Model:BALB/c mouse and Sprague-Dawley rats[1]
Dosage:1 and 5 mg/kg
Administration:po (5 mg/kg) and iv (1 mg/kg)
Result:1.19
speciesroutedose volume (mL/kg)dose (mg/kg)Cmax (μM)AUC (μM·h)Cl (mL/min/kg)T1/2 (h)Vss (L/kg)%F
mouse (BALB/c)IV1.01.01.5402.910
mouse (BALB/c)PO5.0503.82.736
Animal Model:BALB/c mouse and Sprague-Dawley rats[1]
Dosage:1 and 5 mg/kg
Administration:po (5 mg/kg) and iv (1 mg/kg)
Result:1.19
speciesroutedose volume (mL/kg)dose (mg/kg)Cmax (μM)AUC (μM·h)Cl (mL/min/kg)T1/2 (h)Vss (L/kg)%F
rat (Sprague-DawleyIV1.01.00.6703.014
rat (Sprague-DawleyPO2.05.00.21.140
References[1] Zhou D, et al. Discovery of Potent and Highly Selective Interleukin-2-Inducible T-Cell Kinase Degraders with In Vivo Activity. J Med Chem. 2023 Apr 13;66(7):4979-4998. DOI:10.1021/acs.jmedchem.2c02078
[2] Burch JD, et, al. Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J Med Chem. 2014 Jul 10;57(13):5714-27. DOI:10.1021/jm500550e
N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide Preparation Products And Raw materials
Tag:N-[1-[(1S)-3-(dimethylamino)-1-phenylpropyl]pyrazol-4-yl]-6,6-dimethyl-1,4,5,7-tetrahydroindazole-3-carboxamide(1557232-32-2) Related Product Information
[1,1′-Biphenyl]-4-carboxamide, 2′,3′-dichloro-N-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]- (4aS,5aR)-N-[1-[(R)-[(2R)-1,1-dioxothian-2-yl]-phenylmethyl]pyrazol-4-yl]-5,5-difluoro-5a-methyl-1,4,4a,6-tetrahydrocyclopropa[f]indazole-3-carboxamide Protein Tyrosine Kinase Compound Library Phenol, 4-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]-, hydrochloride (1:1) BI-1622 FMF-06-098-1