| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:ABMA
CAS:332108-65-3
Purity:99% Remarks:Reach out to us for more information about custom solutions.
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N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine manufacturers
- ABMA
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- $30.00 / 2mg
-
2025-10-22
- CAS:332108-65-3
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
- ABMA
-
- $30.00 / 2mg
-
2025-10-22
- CAS:332108-65-3
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
- ABMA
-
- $30.00 / 2mg
-
2025-06-04
- CAS:332108-65-3
- Min. Order:
- Purity: 100%
- Supply Ability: 10g
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| | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine Basic information |
| | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine Chemical Properties |
| Boiling point | 428.2±30.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 125 mg/mL (356.85 mM) | | pka | 9.86±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine Usage And Synthesis |
| Uses | ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity[1][2]. | | in vivo | ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD90 of ricin[1]. | Animal Model: | Pathogen-free female BALB/c mice (6 week-old) with ricin[1] | | Dosage: | 2 mg/kg, 20 mg/kg, 200 mg/kg | | Administration: | Intraperitoneal injection | | Result: | A statistically significant protection according to survival curves was observed with a single ip dose of 2?mg/kg. The 20?mg/kg dose fully protected animals through to day 21. The 200?mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.
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| | IC 50 | Leishmania | | References | [1] Wu Y, et al. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments. DOI:10.1038/s41598-017-15466-7
[2] Wu Y, et al. DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses. ACS Med Chem Lett. 2019 Jul 2;10(8):1140-1147. DOI:10.1021/acsmedchemlett.9b00155 |
| | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine Preparation Products And Raw materials |
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