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| | 2-CHLORO-6-METHOXYPYRAZINE Basic information |
| | 2-CHLORO-6-METHOXYPYRAZINE Chemical Properties |
| Boiling point | 183.3±35.0 °C(Predicted) | | density | 1.292±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -1.79±0.10(Predicted) | | form | solid | | Appearance | Off-white to light yellow Solid-liquid mixture | | InChI | 1S/C5H5ClN2O/c1-9-5-3-7-2-4(6)8-5/h2-3H,1H3 | | InChIKey | XWSSFRJLOZQOCX-UHFFFAOYSA-N | | SMILES | COC1=CN=CC(Cl)=N1 |
| Risk Statements | 41 | | Safety Statements | 26-39 | | WGK Germany | WGK 3 | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1 |
| | 2-CHLORO-6-METHOXYPYRAZINE Usage And Synthesis |
| Synthesis | 1. Methanol (MeOH, 0.27 mL, 6.7 mmol) was dissolved in 15 mL of tetrahydrofuran (THF).
2. Add sodium hydride (NaH, 60 wt% mineral oil dispersion, 0.32 g, 8.0 mmol) to the above solution and stir for 30 minutes at room temperature.
3. 2,6-dichloropyrazine (1.0 g, 6.7 mmol) dissolved in 20 mL of THF was added slowly and stirring was continued for 16 hours at room temperature.
4. Upon completion of the reaction, the reaction was quenched by the addition of aqueous ammonium chloride and the reaction mixture was extracted with ether (Et2O).
5. The organic layers were combined, dried over anhydrous magnesium sulfate, filtered and purified by column chromatography to afford the target product, 2-chloro-6-methoxypiperazine (0.71 g, 73% yield).
6. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 8.14 (1H, s), 8.13 (1H, s), 3.99 (3H, s). | | References | [1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0467 |
| | 2-CHLORO-6-METHOXYPYRAZINE Preparation Products And Raw materials |
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