2-Bromo-3-methoxy-6-methylpyridine manufacturers
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| | 2-Bromo-3-methoxy-6-methylpyridine Basic information |
| Product Name: | 2-Bromo-3-methoxy-6-methylpyridine | | Synonyms: | 2-BROMO-3-METHOXY-6-METHYLPYRIDINE;3-Methoxy-6-Picoline;2-Bromo-3-methoxy-6-methylpyridine ,97%;2-bromo-3-methoxy-6-methylpyridine(SALTDATA: FREE);Pyridine, 2-broMo-3-Methoxy-6-Methyl-;2-BROMO-3-METHOXY-6-METHYLPYRIDINE ISO 9001：2015 REACH | | CAS: | 24207-22-5 | | MF: | C7H8BrNO | | MW: | 202.05 | | EINECS: | 214-589-6 | | Product Categories: | Pyridine | | Mol File: | 24207-22-5.mol |  |
| | 2-Bromo-3-methoxy-6-methylpyridine Chemical Properties |
| Boiling point | 244.0±35.0 °C(Predicted) | | density | 1.452±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | -0.21±0.10(Predicted) | | Appearance | Off-white to yellow Solid | | InChI | InChI=1S/C7H8BrNO/c1-5-3-4-6(10-2)7(8)9-5/h3-4H,1-2H3 | | InChIKey | OUJFCUIDDZMCCW-UHFFFAOYSA-N | | SMILES | C1(Br)=NC(C)=CC=C1OC |
| | 2-Bromo-3-methoxy-6-methylpyridine Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis | General procedure for the synthesis of 2-bromo-3-methoxy-6-methylpyridine from 2-bromo-3-hydroxy-6-methylpyridine and iodomethane: 2-bromo-3-hydroxy-6-methylpyridine (7.89 g, 42.0 mmol), potassium carbonate (11.60 g, 83.9 mmol), and iodomethane (8.93 g, 62.9 mmol, 3.92 mL) were mixed in acetone (100 mL) in acetone was stirred. The reaction mixture was heated to reflux overnight. Upon completion of the reaction, the mixture was filtered, the solvent was evaporated and purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 95:5 to 9:1) to afford the target product 2-bromo-3-methoxy-6-methylpyridine as a white solid (7.49 g, 88.3% yield).1H NMR (500 MHz, CDCl3): δ 2.46 (s, 3H), 3.87 (s, 3H), 3.87 (s, 3H). 3.87 (s, 3H), 7.04 (d, J = 8.0 Hz, 1H), 7.10 (d, J = 8.0 Hz, 1H). | | References | [1] Tetrahedron Letters, 1995, vol. 36, # 30, p. 5319 - 5322
[2] Journal of Organic Chemistry, 1996, vol. 61, # 14, p. 4623 - 4633
[3] Patent: US2003/83357, 2003, A1
[4] Patent: US6515003, 2003, B1
[5] Patent: EP3255042, 2017, A2. Location in patent: Paragraph 0122; 0124 |
| | 2-Bromo-3-methoxy-6-methylpyridine Preparation Products And Raw materials |
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