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| | Triethylamine trihydrofluoride Basic information | | Application |
| | Triethylamine trihydrofluoride Chemical Properties |
| Melting point | -29--27°C | | Boiling point | 70 °C15 mm Hg(lit.) | | density | 0.989 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.3915(lit.) | | Fp | 190 °F | | storage temp. | Store below +30°C. | | solubility | soluble in Chloroform, Hexane | | form | Liquid | | Specific Gravity | 0.989 | | color | Clear yellow to brown | | PH | 3 (H2O, 20℃)(saturated aqueous solution) | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 5522945 | | Exposure limits | ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3 | | CAS DataBase Reference | 73602-61-6(CAS DataBase Reference) | | EPA Substance Registry System | Ethanamine, N,N-diethyl-, trihydrofluoride (73602-61-6) |
| | Triethylamine trihydrofluoride Usage And Synthesis |
| Application | The t-butyldimethylsilyl (TBDMS) group is the most widely used 2'-OH protection in synthesis of oligoribonucleotides. The TBDMS-group became much used particularly after it was combined with phosphoroamidite methodology and was also the choice when H-phosphonate based RNA-synthesis was introduced. Removal of TBDMS-protection is most commonly done with 1 M tetrabutylammonium fluoride (TBAF) in tetrahydrofuran (THF). These conditions has proven efficient.
| | Chemical Properties | clear yellow liquid | | Uses | Triethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams. | | Uses | Mild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta. | | General Description | Triethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds. |
| | Triethylamine trihydrofluoride Preparation Products And Raw materials |
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