| Company Name: |
Shenzhen Nexconn Pharmatechs Ltd |
| Tel: |
+86-755-89396905 +86-15013857715 |
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admin@nexconn.com |
| Products Intro: |
Product Name:Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine)/Annexin-1 (2-12) (human, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (human, bovine, chicken, porcine)
CAS:256447-08-2
Purity:98% Package:1KG;10KG;50KG
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| Product Name: | AC2-12 | | Synonyms: | Annexin A1 (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine)
Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine);Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine);Annexin A1;ANTI-ANNEXIN A1 (CENTER) antibody produced in rabbit;ANX1;LPC1;Annexin 1 (ANXA - 1;Annexin A1 (1-11) (dephosphorylated) | | CAS: | 256447-08-2 | | MF: | C63H94N14O17S | | MW: | 1351.57 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 256447-08-2.mol |  |
| | AC2-12 Chemical Properties |
| storage temp. | -20°C | | form | Solid | | color | White to off-white | | biological source | rabbit | | Water Solubility | Soluble to 1 mg/ml in 20% acetonitrile / Water | | Sequence | Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH |
| Storage Class | 10 - Combustible liquids |
| | AC2-12 Usage And Synthesis |
| Uses | Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2]. | | Enzyme inhibitor | This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice. | | in vivo | Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)[1].
Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice[2].
| | References | [1] L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14535-9. DOI:10.1073/pnas.95.24.14535
[2] M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73. DOI:10.1016/S0002-9440(10)64667-6 |
| | AC2-12 Preparation Products And Raw materials |
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