- Methyl 3-bromopropionate
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- $8.00 / 1KG
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2025-09-25
- CAS:3395-91-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | Methyl 3-bromopropionate Basic information |
| | Methyl 3-bromopropionate Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-37/39-24/25 | | WGK Germany | 3 | | RTECS | UA2451790 | | TSCA | TSCA listed | | HS Code | 29159080 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Methyl 3-bromopropionate Usage And Synthesis |
| Chemical Properties | Very slightly yellow liquid | | Uses | Methyl 3-bromopropionate was used in the synthesis of spiroanellated γ-lactones, pinacols and unprecedented 3-(1-hydroxycycloalkyl)-l-oxaspiro[n,m]alkan-2-ones. | | Synthesis | Methyl propiolate (52 mL, 0.583 mol) was mixed with recrystallized N-bromosuccinimide (120 g, 0.674 mol) in 1,700 mL of acetone under nitrogen protection. Pure silver nitrate (9.9 g, 0.0583 mol) was added to the solution in a single addition and the reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the acetone was evaporated under reduced pressure (25 °C bath temperature) to give a gray slurry. The slurry was washed with hexane (2 x 200 mL), filtered to remove the gray solid, and the filtrate was concentrated under vacuum to give 95 g of a pale yellow oily crude product. The crude product was passed through a short distillation under reduced pressure (65 °C, ca. 25 mmHg) and the fractions were collected with a receiver cooled with dry ice/acetone to give 83.7 g (88% yield) of methyl 3-bromopropynoate as a pale yellow oil. Calculated values for elemental analysis of [C4H3BrO2]: C, 29.48; H, 1.86. Measured values: C, 29.09; H, 1.97. | | References | [1] Patent: WO2004/13137, 2004, A1. Location in patent: Page 76
[2] Tetrahedron Letters, 2010, vol. 51, # 13, p. 1793 - 1796 |
| | Methyl 3-bromopropionate Preparation Products And Raw materials |
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