5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one

Request For Quotation
5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one manufacturers
5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one Basic information
Product Name:5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one
Synonyms:5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one;A1AR antagonist 5;Pyrido[2,3-d]pyrimidin-4(3H)-one, 5-(4-chlorophenyl)-2-(1-pyrrolidinyl)-
CAS:1030509-01-3
MF:C17H15ClN4O
MW:326.78
EINECS:
Product Categories:
Mol File:1030509-01-3.mol
5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one Structure
5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one Chemical Properties
Boiling point 531.5±60.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
pka0.81±0.20(Predicted)
Safety Information
MSDS Information
5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one Usage And Synthesis
UsesA1AR antagonist 5 (compound 20) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.83 and a pKi of 6.11[1].
IC 50hA1AR: 6.11 (pKi); hA2AAR: <4 (pKi)
References[1] Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936. DOI:10.1016/j.ejmech.2019.111936
5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one Preparation Products And Raw materials
Tag:5-(4-chlorophenyl)-2-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidin-4-one(1030509-01-3) Related Product Information