溶剂绿 7
| 中文名称 | 溶剂绿 7 |
|---|---|
| 中文同义词 | 8-羟基芘-1,3,6-三磺酸三钠盐;溶剂绿 7(>85.0%(E));8-羟基芘-1,3,6-三磺酸;PYRANINE 水合物;溶剂绿 7 水合物;8-羟基-1,3,6-芘三磺酸三钠 85%(溶剂绿7);8-羟基芘-1,3,6-三磺酸 三钠盐 水合物;HPTS[8-羟基芘-1,3,6-三磺酸三钠盐]*荧光参照标准* |
| 英文名称 | Solvent Green 7 |
| 英文同义词 | 1,3,6-Pyrenetrisulfonicacid,8-hydroxy-,trisodiumsalt;11389green;3,6-pyrenetrisulfonicacid,8-hydroxy-trisodiumsalt;8-hydroxypyrene-1,3,6-trisulfonicacidsodiumsalt;c.i.solventgreen7;c.i.solventgreen9;SOLVENT GREEN 7;PYRANINE |
| CAS号 | 6358-69-6 |
| 分子式 | C16H7Na3O10S3 |
| 分子量 | 524.39 |
| EINECS号 | 228-783-6 |
| 相关类别 | 颜料及染料类;荧光探针，标记，颗粒和染色;化工原料;钠盐;染料;Dyes and Pigments;Aromatic Nitriles;Pyrenes;Fluorescent Indicators and Probes;Fluorescent Probes;材料中间体;其他原料;助剂;日用化工;化工产品;Labels;Luminescent Compounds/Detection;Particles and Stains;pH Sensitive Probes and Indicators;Sulfonic/Sulfinic Acids;Wavelength Index;Alphabetical;Biochemicals and Reagents;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds |
| Mol文件 | 6358-69-6.mol |
| 结构式 |  |
溶剂绿 7 性质
| 熔点 | 62-63.5 °C(lit.) |
|---|---|
| 沸点 | 171-178 °C10 mm Hg(lit.) |
| 密度 | 2.15 |
| 蒸气压 | 0Pa at 25℃ |
| 闪点 | 250 °C |
| 储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | 溶于甲醇，溶解度为0.1g/mL，澄清 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 7.3, (at 22℃) |
| 色指数 | 59040 |
| 颜色 | 粘黄色 |
| 水溶解性 | 300 g/L (25 ºC) |
| 最大波长(λmax) | 403 nm (Buffer pH 4.0); 454 nm (Buffer pH 9.0) |
| Merck | 7954 |
| BRN | 4107272 |
| 生物领域应用 | Antiperspirants; bath preparations; cleansing products; cosmetics; contact lens; hair dyes; hygiene products/soaps; food products; controlled-release system for proteins; drug delivery; in ophthalmology/retinal surgery; sugar sensors (glucose, fructose, lactose, sucrose); as a substrate for measuring acetylcholinesterase (AChE) activity, carbonic anhydrase activity, esterases activity, β-glucuronidase activity, lipase activity, acidic/alkaline phosphatases activity, pyrophosphatase activity, sucrose phosphorylase (SPO) activity, phosphoglucomutase (PGM) activity; treating cancer, infection, immune/autoimmune disease, mastitis, tonsillitis, tuberculosis |
| 主要应用 | Adhesives; agrochemicals; ammonia sensor; carbon dioxide sensor; oxygen sensor; anionic surfactants sensor; measuring the size of the organoclay aggregates; detecting cracks/flaws in metallic surfaces, refrigerant leaking; detergents; correction fluid; highlighters; inks; markers; paints; pencils; toners; chemically amplified resist; color filters; chemiluminescent materials; electrophoretic display (EPD) film materials; electroluminescent displays/materials; fuel cell; lasers; liquid crystal displays; luminescent materials; nanoparticles; papers; photoresist processes; photonic ionic liquids; soils; solar cell; sol–gel materials/processes/thin films; sonophotoluminescence; water tracers; evaluating liquid water flow in wood during drying |
| 化妆品成分功效 | COLORANT HAIR DYEING |
| InChIKey | DCEGPALHGHQUSK-UHFFFAOYSA-K |
| SMILES | OC1=C2C(C3=C(C=C4)C(S(=O)([O-])=O)=CC(S(=O)([O-])=O)=C3C=C2)=C4C(S(=O)([O-])=O)=C1.O.[Na+].[Na+].[Na+] |
| LogP | -3.97 at 25℃ |
| CAS 数据库 | 6358-69-6(CAS DataBase Reference) |
| EPA化学物质信息 | C.I. Solvent Green 7 (6358-69-6) |
Pyranine is capable of discriminating ranges of cations from the Cu
+
ion, even in competing environment. Pyranine displays a rapid fluorescence response (t
1/2
=1.66 min) towards the Cu
+
ion, and the micromolar detection limit enables the detection of the ion in environmental samples. The observed stoichiometry of complexation between Pyranine and Cu
+
is 2:1.
The pH-sensitive fluorescent indicator Pyranine is studied to determine its usefulness as probes for the living cornea and anterior chamber. Adequate concentrations are reached in the cornea and anterior chamber after topical administration; measurements can be made by fluorophotometry for many hours. The pH is calculated by measuring the ratio of fluorescent intensity at two excitation wavelengths, I463/I404, a measurement which is dependent on pH but independent of the concentration of the fluorophore and other variables which can alter the intensity. In the rabbit eye, Pyranine in the cornea and anterior chamber is observed to undergo easily measurable changes in fluorescent ratios associated with lid closure and contact lens wear, indicating its sensitivity to mild changes in pH.
59572-10-0
6358-69-6
以1,3,6,8-芘四磺酸四钠盐为原料合成溶剂绿7的一般步骤如下：在2000毫升三颈烧瓶中加入1200克浓硫酸，搅拌下加入120克1,3,6,8-芘四磺酸四钠盐，轻微加热以促进完全溶解后，缓慢升温至90°C并维持1小时。反应完成后，用水浴将反应混合物冷却至40°C以下，缓慢滴加480克液体硫磺黑，滴加过程控制在3小时内完成。随后，将反应温度维持在100°C左右继续反应5小时。反应结束后，冷却至室温，将反应混合物倒入720克冰水中，得到粘稠物料，经过滤后干燥滤饼，得到芘四磺酸四钠盐。接下来，将芘四磺酸四钠盐溶于1000毫升水中，转移至2000毫升三口烧瓶中，用氢氧化钠溶液调节至中性，再加入300克片状氢氧化钠。缓慢加热至微沸状态，保持5小时。反应完成后，冷却，先用盐酸调节pH值至7左右，然后加入100克氯化钠搅拌至完全溶解，缓慢沉淀出淡黄色固体。经过滤、干燥，最终得到约245克8-羟基-1,3,6-芘三钠磺酸盐。
参考文献：
[1] Patent: CN105272886, 2016, A. Location in patent: Paragraph 0013; 0026; 0027
安全信息
| 危险品标志 | Xn,Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 36/37-37/39-26-36 |
| WGK Germany | 3 |
| RTECS号 | UR2700000 |
| TSCA | TSCA listed |
| 海关编码 | 29089990 |
| 存储类别 | 11 - 可燃固体 |
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