- Trimeprazine tartrate
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- $0.00 / 25KG
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2025-12-01
- CAS:4330-99-8
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
- Trimeprazine tartrate
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- $1.10 / 1g
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2025-11-18
- CAS:4330-99-8
- Min. Order: 1g
- Purity: 99.9% Min
- Supply Ability: 100 Tons
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| | Trimeprazine tartrate Basic information |
| | Trimeprazine tartrate Chemical Properties |
| Melting point | 153-155°C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol | | form | Solid | | color | White to Almost white | | Merck | 14,9704 | | Major Application | pharmaceutical (small molecule) | | InChIKey | ZEEPCWVFSHMOPI-MVELKYERNA-N | | SMILES | C(N1C2=CC=CC=C2SC2C=CC=CC1=2)C(C)CN(C)C.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:21,26,r| | | CAS DataBase Reference | 4330-99-8(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | RIDADR | 3249 | | WGK Germany | 3 | | RTECS | SO6475000 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 2934302700 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | Trimeprazine tartrate Usage And Synthesis |
| Chemical Properties | White to Off-White Solid | | Uses | Antipruritic. Antibacterial, antimicrobial agent | | Brand name | Temaril (Allergan). | | General Description | Trimeprazine tartrate, (±)10-[3-(dimethylamino)-2-methylpropyl] phenothiazine tartrate(Temaril), occurs as a white to off-white crystalline powderthat is freely soluble in water and soluble in alcohol. Its antihistaminicaction is reported to be from 1.5 to 5 times thatof promethazine. Clinical studies have shown it has a pronouncedantipruritic action that may be unrelated to itshistamine-antagonizing properties. | | in vivo | Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 3 weeks) promotes mouse β-cell growth[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 22 days) synergistically reduces the progression of diabetes in NOD mice[2].
Alimemazine hemitartrate (10 mg/kg, intraperitoneal injection, once a day for 7 days) promotes the proliferation and survival of β-cells in normal mice, but has little effect on β-cell defects caused by IRS2 deficiency[2].
Alimemazine hemitartrate (10 mg/kg, oral gavage, two doses) does not reduce mouse lung virus titers[3]. | Animal Model: | Pdx1+/– mice[2] | | Dosage: | 10 mg/kg, once a day for 3 weeks | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Increased HOMA 2%B and normalized glucose tolerance in mice. |
| Animal Model: | Irs2-/–mice[2] | | Dosage: | 10 mg/kg, once a day for seven days | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Did not restore the function of β cells, but promoted β cell growth and increased the area of β cells in normal mice.
Increased the concentration of IRS2 protein, had no effect on glucose tolerance in mice, and did not change the insulin sensitivity of mice.
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| Animal Model: | SARS-CoV-2 multiplication in mice[3] | | Dosage: | 10mg/kg, at 1 h prior to and 24 h after virus inoculation | | Administration: | i.g. | | Result: | Did not reduce lung virus titers. |
| | IC 50 | GPCR |
| | Trimeprazine tartrate Preparation Products And Raw materials |
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