β-Apo-oxytetracycline manufacturers
|
| | β-Apo-oxytetracycline Basic information |
| | β-Apo-oxytetracycline Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 63 | | Safety Statements | 45-36/37 | | HS Code | 29413020 |
| Provider | Language |
|
ACROS
| English |
| | β-Apo-oxytetracycline Usage And Synthesis |
| Description | β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis. | | Chemical Properties | yellow-brown to brown powder | | Uses | Oxytetracycline metabolite (absolute stereochemistry unknown) | | Uses | β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability. | | Uses | β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability. | | References | [1] ANNE KRUSE LYKKEBERG . Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS[J]. Journal of pharmaceutical and biomedical analysis, 2004, 34 2: Pages 325-332. DOI: 10.1016/s0731-7085(03)00500-4
[2] B. HALLING-SRENSEN J. T G Sengelv. Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria[J]. Archives of Environmental Contamination and Toxicology, 2002, 42 3: 263-271. DOI: 10.1007/s00244-001-0017-2
[3] N. HUE. PRELIMINARY STUDIES ON THE TOXIC EFFECTS OF DEGRADATION PRODUCTS OF OXYTETRACYCLINE AND CHLORTETRACYCLINE ON RATS[J]. Hue University Journal of Science: Natural Science, 2015, 438 1: 467-475. DOI: 10.17265/2161-6256/2015.12.004 |
| | β-Apo-oxytetracycline Preparation Products And Raw materials |
|