N-苄基-对甲苯磺酸胺
| 中文名称 | N-苄基-对甲苯磺酸胺 |
|---|---|
| 中文同义词 | N-苄基-对甲苯磺酸胺;N-苄基-对甲苯磺酰胺;N-苄基-4-甲基苯磺酰胺;N-苄基对甲苯磺酰胺(BTS);肌球蛋白S1ATP酶抑制剂(BTS);N-对甲苯磺酰基基苄胺;N-苄基对甲苯磺酰胺价格;BTS,CA2+-STIMULATED MYOSIN S1 ATPASE |
| 英文名称 | BTS |
| 英文同义词 | n-benzyl-p-toluenesulfonamid;N-BENZYL-P-TOLUENESULFONAMIDE;N-BENZYL-P-TOLUENESULPHONAMIDE;LABOTEST-BB LT00786416;BTS;4-METHYL-N-(PHENYLMETHYL)BENZENESULFONAMIDE;N-BENZYL-4-METHYL-BENZENESULFONAMIDE;N-Tosylbenzylamine |
| CAS号 | 1576-37-0 |
| 分子式 | C14H15NO2S |
| 分子量 | 261.34 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;合成;医药中间体;苯环化合物;A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~5 μM) and reversibly blocks the gliding motility.;Inhibitors;ATPase |
| Mol文件 | 1576-37-0.mol |
| 结构式 |  |
N-苄基-对甲苯磺酸胺 性质
| 熔点 | 115 °C |
|---|---|
| 沸点 | 419.1±48.0 °C(Predicted) |
| 密度 | 1.204±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 可溶于氯仿（少许）、可溶于二氯甲烷、乙酸乙酯（少许） |
| 形态 | 白色结晶固体 |
| 酸度系数(pKa) | 11.54±0.30(Predicted) |
| 颜色 | 白色至类白色 |
| 敏感性 | Light Sensitive |
| InChI | InChI=1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3 |
| InChIKey | WTHKAJZQYNKTCJ-UHFFFAOYSA-N |
| SMILES | C1(S(NCC2=CC=CC=C2)(=O)=O)=CC=C(C)C=C1 |
| CAS 数据库 | 1576-37-0(CAS DataBase Reference) |
BTS (N-Benzyl-p-toluenesulfonamide) 是一种有效和选择性的骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂，对肌动蛋白和 Ca2+ 刺激的肌球蛋白 S1 ATPase 的 IC50 值约为 5 µM。BTS 可特异性抑制骨骼肌快速纤维的收缩。
IC50: ~5 µM (skeletal muscle myosin II S1 ATPase)
BTS (2-12 μM) inhibits the Ca
2+
-stimulated ATPase activity of myosin S1 in the absence of actin, with an IC
50
of ~5 µM.
BTS (2-20 μM) reversibly inhibits the gliding motility rate of heavy meromyosin (HMM).
BTS (100 μM) releases myosin from actin in the presence of ADP.
BTS (0-20 μM) reversibly inhibits isometric Ca
2+
-activated tension in skinned skeletal muscle fibres from rabbit and frog, with IC
50
s of ~3 µM and 1 µM, respectively.
用途
A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin鈥檚 interaction with F-actin. Does not
affect platelet myosin II.安全信息
| RTECS号 | XT5490000 |
|---|---|
| 海关编码 | 2935.90.9500 |
| 毒性 | rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 41, 1953. |