- Acedoben
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- $29.00 / 1g
-
2026-04-21
- CAS:556-08-1
- Min. Order:
- Purity: 99.91%
- Supply Ability: 10g
- Acedoben
-
- $29.00 / 1g
-
2026-04-21
- CAS:556-08-1
- Min. Order:
- Purity: 99.91%
- Supply Ability: 10g
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| | 4-acetamidobenzoic acid Basic information |
| | 4-acetamidobenzoic acid Chemical Properties |
| Melting point | 259-262 °C (dec.)(lit.) | | Boiling point | 311.69°C (rough estimate) | | density | 1.2822 (rough estimate) | | refractive index | 1.5600 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Powder | | pka | pK1: 4.28 (25°C) | | color | Off-white to slightly beige | | Water Solubility | <0.1 g/100 mL at 21 ºC | | BRN | 390602 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | Major Application | peptide synthesis | | InChI | 1S/C9H9NO3/c1-6(11)10-8-4-2-7(3-5-8)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13) | | InChIKey | QCXJEYYXVJIFCE-UHFFFAOYSA-N | | SMILES | CC(=O)Nc1ccc(cc1)C(O)=O | | CAS DataBase Reference | 556-08-1(CAS DataBase Reference) | | NIST Chemistry Reference | N-(4-Carboxyphenyl)acetic acid amide(556-08-1) | | EPA Substance Registry System | Benzoic acid, 4-(acetylamino)- (556-08-1) |
| Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | TSCA | TSCA listed | | REACH Registrations | Active | | HS Code | 29242995 | | Storage Class | 11 - Combustible Solids |
| | 4-acetamidobenzoic acid Usage And Synthesis |
| Description | 4-Acetamidobenzoic acid (PAcBA) is a naturally occurring acetylated metabolite of 4-aminobenzoic acid and is a component of the antiviral and immunostimulatory drug inosine pranobex (Inosiplex; Isoprinosine; Methisoprinol). | | Chemical Properties | white or off-white powder or crystals | | Originator | 4-Acetamidobenzoic acid ,ARIAC | | Uses | immune stimulant (component) | | Uses | Acedoben is the acetylated derivative of p-aminobenzoic acid (PABA). Acedoben is a metabolite of the anesthetic Benzocaine (B202970). | | Definition | ChEBI: 4-acetamidobenzoic acid is a amidobenzoic acid that consists of benzoic acid bearing an acetamido substituent at position 4. It is functionally related to a 4-aminobenzoic acid. It is a conjugate acid of a 4-acetamidobenzoate. | | Manufacturing Process | Into a 2 L, 3-necked flask set in a tub and equipped with a stirrer, an air
condenser (drying tube), thermometer, was placed 860 ml of water, 43.0 g of
MgSO4 and 43.0 g of sodium acetate and heated on water bath. Into heated
solution to 70°C stirring 43.0 g of N-p-tolylacetamide were added. Then 136.0
g of KMnO4 by small portions were added at 75°-80°C. The reaction mixture
allow to stand for 6 h and stirring was continue till the solution became
colorless. Hot solution was filtered and filtrate treated hydrochloric acid to
slightly acidic pH. After that 44.0 g (85%) of p-acetoaminobenzoic acid was
obtained as white precipitate, melting point 250°C. | | Therapeutic Function | Antiviral | | General Description | Needles or off-white powder. | | Air & Water Reactions | Water insoluble. | | Reactivity Profile | Simultaneously an amide and a carboxylic acid. | | Fire Hazard | Flash point data for p-Acetylamino benzoic acid are not available; however, p-Acetylamino benzoic acid is probably combustible. | | reaction suitability | reaction type: solution phase peptide synthesis | | References | [1] Synthetic Communications, 2008, vol. 38, # 7, p. 1028 - 1035
[2] Applied Catalysis A: General, 2013, vol. 456, p. 118 - 125
[3] Green Chemistry, 2012, vol. 14, # 3, p. 847 - 854
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 9, p. 1274 - 1281
[5] Synthetic Communications, 2008, vol. 38, # 17, p. 2929 - 2940 |
| | 4-acetamidobenzoic acid Preparation Products And Raw materials |
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