N-(4-溴苯基)-4-苯基噻唑-2-胺
| 中文名称 | N-(4-溴苯基)-4-苯基噻唑-2-胺 |
|---|---|
| 中文同义词 | N-(4-溴苯基)-4-苯基噻唑-2-胺;化合物RCGD423;RCGD 423,GP130调制器;化合物RCGD423,10 MM DMSO 溶液;RCGD 423 (RCGD423);RCGD423 ,S6579 |
| 英文名称 | 4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine |
| 英文同义词 | 4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine;RCGD423;2-Thiazolamine, N-(4-bromophenyl)-4-phenyl-;RCGD 432;N-(4-Bromophenyl)-4-phenylthiazol-2-amine;RCGD423,inhibit,RCGD 423,Inhibitor,Interleukin Related,RCGD-423;Regulator of cartilage growth and differentiation (RCGD) 423;RC D423 |
| CAS号 | 108237-91-8 |
| 分子式 | C15H11BrN2S |
| 分子量 | 331.23 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 108237-91-8.mol |
| 结构式 |  |
N-(4-溴苯基)-4-苯基噻唑-2-胺 性质
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
|---|---|
| 溶解度 | DMSO:34.0(最大浓度 mg/mL);102.6(最大浓度 mM) 乙醇:34.0(最大浓度 mg/mL);102.6(最大浓度 mM) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
RCGD-423 是 Glycoprotein 130 (gp130, IL6ST, IL6-beta, CD130) 信号调节剂，可调节软骨生长和分化。
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IL6-beta
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RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S6579 | 108237-91-8 RCGD423 | 108237-91-8 | 5mg | 795.42元 |
| 2026/03/03 | S6579 | 108237-91-8 RCGD423 | 108237-91-8 | 25mg | 2433.42元 |