METHYLLYCACONITINE CITRATE
| 中文名称 | METHYLLYCACONITINE CITRATE |
|---|---|
| 中文同义词 | 甲基牛扁亭柠檬酸盐;化合物 T12017;甲基牛扁亭柠檬酸盐,10 MM DMSO 溶液;Methyllycaconitine citrate试剂;试剂Methyllycaconitine citrate;Methyllycaconitine citrate试剂;试剂Methyllycaconitine citrate;((3S,6S,6aS,7R,7aR,8S,9R,10S,11aR,12S,12aS,13S,14R)-1-乙基-11a,12-二羟基-6,8,10,13-四甲氧基十二氢-2H-3,6a,12-(表乙烷[1,1,2]三基)-7,9-甲桥萘并[2,3-b]氮杂环辛烯-3(4H)-基)甲基 2-((S)-3-甲基-2,5-二氧代吡咯烷-1-基)苯甲酸酯 2-羟基丙烷-1,2,3-三羧酸(1:1) |
| 英文名称 | Methyllycaconitine (citrate) |
| 英文同义词 | Methyllycaconitine citrate, 10 mM in DMSO;(10S)-Methyllycaconitine citrate;((3S,6S,6aS,7R,7aR,8S,9R,10S,11aR,12S,12aS,13S,14R)-1-Ethyl-11a,12-dihydroxy-6,8,10,13-tetramethoxydodecahydro-2H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-3(4H)-yl)methyl 2-((S)-3-methyl-2,5-dioxopyrrolidin-1-yl)benzoate 2-hydroxypropane-1,2,3-tricarboxylate(1:1);Methyllycaconitine citrate (1:1) |
| CAS号 | 351344-10-0 |
| 分子式 | C43H58N2O17 |
| 分子量 | 874.93 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 351344-10-0.mol |
| 结构式 |  |
METHYLLYCACONITINE CITRATE 性质
| 储存条件 | Desiccate at -20°C |
|---|---|
| 溶解度 | 可溶于水 |
| 形态 | 固体 |
| 颜色 | 白色至黄色 |
α7nAChR
Pretreatment with 5 and 10 µM Methyllycaconitine citrate (MLA) inhibits the decreased cell viability induced by Aβ 25-35 . Cell viability does not decrease after exposure to Methyllycaconitine citrate (2.5, 5, 10, 20 µM). Aβ 25-35 treatment increases LC3-II levels, which is inhibited by administration of Methyllycaconitine citrate. Methyllycaconitine citrate also inhibits Aβ-induced autophagosome accumulation in SH-SY5Y cells. Flow cytometry also demonstrates decreased MDC-labeled vacuoles with Methyllycaconitine citrate treatment.
Methyllycaconitine citrate (MLA) (6 mg/kg) given alone intraperitoneally does not cause climbing behavior when compare with the saline group. Pretreatment with Methyllycaconitine citrate significantly inhibits methamphetamine (METH)-induced climbing behavior, by about 50%. Methyllycaconitine citrate does not modify either basal locomotor activity or METH-induced hyperlocomotion. The METH-induced depletion of dopamine neuron terminals is attenuated in mice pretreated with Methyllycaconitine citrate (250±43 fmol/mg, n=7). A direct effect of Methyllycaconitine citrate on body temperature is ruled out because Methyllycaconitine citrate does not affect basal body temperature (37.0±0.5°C, n=5) or reduce the METH-induced hyperthermia (38.2±0.4°C, n=6, MLA+METH group, n.s. versus METH group).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-N2332A | METHYLLYCACONITINE CITRATE Methyllycaconitine citrate | 351344-10-0 | 5 mg | 910元 |
| 2026/09/15 | HY-N2332A | METHYLLYCACONITINE CITRATE Methyllycaconitine citrate | 351344-10-0 | 10 mg | 1600元 |