Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp

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Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp Basic information
Product Name:Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp
Synonyms:Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp;L-Glutamamide, N-(2-aminobenzoyl)-L-valyl-L-alanyl-L-α-aspartyl-L-norvalyl-L-arginyl-L-α-aspartyl-L-arginyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-
CAS:1042405-14-0
MF:C53H80N20O18
MW:1285.33
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Mol File:1042405-14-0.mol
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp Structure
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp Chemical Properties
density 1.54±0.1 g/cm3(Predicted)
form Solid
pka4.19±0.10(Predicted)
color White to yellow
Sequence{Abz}-Val-Ala-Asp-{Nva}-Arg-Asp-Arg-Gln-{EDDnp}
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MSDS Information
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp Usage And Synthesis
UsesAbz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1), and can be used for detection of proteinase 3 (PR3) activity[1][2].
References[1] Yu J, et al. Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury. Redox Biol. 2024 Jun 6;74:103231. DOI:10.1016/j.redox.2024.103231
[2] Korkmaz B, et al. Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates. Methods Mol Biol. 2012;844:125-38. DOI:10.1007/978-1-61779-527-5_9
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp Preparation Products And Raw materials
Tag:Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp(1042405-14-0) Related Product Information
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