PF-DcpSi

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PF-DcpSi Suppliers list
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Email: 15151849396@163.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
PF-DcpSi Basic information
Product Name:PF-DcpSi
Synonyms:PF-DcpSi;Benzonitrile, 3-[(2,4-diamino-5-quinazolinyl)methoxy]-5-fluoro-
CAS:2092917-19-4
MF:C16H12FN5O
MW:309.3
EINECS:
Product Categories:
Mol File:2092917-19-4.mol
PF-DcpSi Structure
PF-DcpSi Chemical Properties
Boiling point 598.1±60.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
pka7.84±0.10(Predicted)
Safety Information
MSDS Information
PF-DcpSi Usage And Synthesis
UsesPF-DcpSi is a mRNA decapping scavenger enzyme (DcpS) inhibitor (IC50: 0.11 nM). PF-DcpSi (30 mg/kg,i.p.) ameliorates the disease phenotype in a mice model of spinal muscular atrophy (SMA)[1].
References[1] Gopalsamy A, et al. Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem. 2017 Apr 13;60(7):3094-3108. DOI:10.1021/acs.jmedchem.7b00124
PF-DcpSi Preparation Products And Raw materials
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