3-[ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-N-[(2;3;5;6;7;8-HEXAHYDRO-1-METHYL-3-OXO-4-ISOQUINOLINYL)METHYL]-2-METHYL-5-[6-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINYL]-BENZAMIDE
概述 用途与合成方法 MSDS 3-[ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-N-[(2;3;5;6;7;8-HEXAHYDRO-1-METHYL-3-OXO-4-ISOQUINOLINYL)METHYL]-2-METHYL-5-[6-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINYL]-BENZAMIDE价格(试剂级) 上下游产品信息
| 中文名称 | 3-[ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-N-[(2;3;5;6;7;8-HEXAHYDRO-1-METHYL-3-OXO-4-ISOQUINOLINYL)METHYL]-2-METHYL-5-[6-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINYL]-BENZAMIDE |
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| 中文同义词 | 化合物 T29231;化合物ZLD1039;ZLD 1039,EZH2抑制剂;3-(乙基(四氢-2H-吡喃-4-基)氨基)-2-甲基-N-((1-甲基-3-氧代-2,3,5,6,7,8-六氢异喹啉-4-基)甲基)-5-(6-(4-甲基哌嗪-1-基)吡啶-3-基)苯甲酰胺 |
| 英文名称 | ZLD-1039 |
| 英文同义词 | ZLD-1039;3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2;3-[ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-N-[(2;3;5;6;7;8-HEXAHYDRO-1-METHYL-3-OXO-4-ISOQUINOLINYL)METHYL]-2-METHYL-5-[6-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINYL]-BENZAMIDE;8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-benzamide;Benzamide, 3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-;3-(Ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)-5-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)benzamide;3-[ethyl(oxan-4-yl)amino]-2-methyl-N-[(1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl]-5-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]benzamide |
| CAS号 | 1826865-46-6 |
| 分子式 | C36H48N6O3 |
| 分子量 | 612.8 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1826865-46-6.mol |
| 结构式 | ![3-[ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-N-[(2;3;5;6;7;8-HEXAHYDRO-1-METHYL-3-OXO-4-ISOQUINOLINYL)METHYL]-2-METHYL-5-[6-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINYL]-BENZAMIDE 结构式](CAS/20200611/GIF/1826865-46-6.gif) |
3-[ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-N-[(2;3;5;6;7;8-HEXAHYDRO-1-METHYL-3-OXO-4-ISOQUINOLINYL)METHYL]-2-METHYL-5-[6-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINYL]-BENZAMIDE 性质
| 沸点 | 826.8±65.0 °C(Predicted) |
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| 密度 | 1.24±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 可溶于DMSO |
| 酸度系数(pKa) | 12.15±0.60(Predicted) |
| 形态 | 结晶固体 |
| 颜色 | 米白色至灰色 |
| InChIKey | SZAYCVHJDOWSNY-UHFFFAOYSA-N |
| SMILES | C(NCC1=C2C(=C(C)NC1=O)CCCC2)(=O)C1=CC(C2=CC=C(N3CCN(C)CC3)N=C2)=CC(N(CC)C2CCOCC2)=C1C |
3-[ETHYL(TETRAHYDRO-2H-PYRAN-4-YL)AMINO]-N-[(2;3;5;6;7;8-HEXAHYDRO-1-METHYL-3-OXO-4-ISOQUINOLINYL)METHYL]-2-METHYL-5-[6-(4-METHYL-1-PIPERAZINYL)-3-PYRIDINYL]-BENZAMIDE 用途与合成方法
ZLD1039 是一种口服有效的、高选择性 EZH2 抑制剂。ZLD1039 高效抑制 EZH2 野生型及 Y641F 和 A677G 突变型，IC50 分别为 5.6、15 和 4.0 nM。ZLD1039 抑制乳腺肿瘤的生长和转移。
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-116804 | ZLD1039 | 1826865-46-6 | 1 mg | 600元 |
| 2025/12/22 | HY-116804 | ZLD1039 | 1826865-46-6 | 5 mg | 1400元 |