- 1-Methylisatin
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- $0.00 / 1kg
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2026-05-01
- CAS:2058-74-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: Customise
- 1-methylisatin
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- $2.20 / 100kg
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2026-04-17
- CAS:2058-74-4
- Min. Order: 1kg
- Purity: 99%min
- Supply Ability: 100kg
- 1-Methylisatin 97%
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- $15.00 / 1KG
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2021-07-02
- CAS:2058-74-4
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | N-METHYLISATIN Basic information |
| | N-METHYLISATIN Chemical Properties |
| Melting point | 130-133 °C (lit.) | | Boiling point | 287.44°C (rough estimate) | | density | 1.314 | | refractive index | 1.5050 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Crystalline Powder | | pka | -2.41±0.20(Predicted) | | color | Orange to brownish | | Water Solubility | Insoluble in water. | | λmax | 427nm(CH2Cl2)(lit.) | | BRN | 128280 | | InChI | InChI=1S/C9H7NO2/c1-10-7-5-3-2-4-6(7)8(11)9(10)12/h2-5H,1H3 | | InChIKey | VCYBVWFTGAZHGH-UHFFFAOYSA-N | | SMILES | N1(C)C2=C(C=CC=C2)C(=O)C1=O | | CAS DataBase Reference | 2058-74-4(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 25-37/38-41 | | Safety Statements | 26-39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | NL7939000 | | HazardClass | IRRITANT | | HS Code | 29337900 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 | | Toxicity | mouse,LD50,intraperitoneal,685mg/kg (685mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Pharmaceutical Chemistry Journal Vol. 15, Pg. 858, 1981. |
| | N-METHYLISATIN Usage And Synthesis |
| Chemical Properties | ORANGE TO BROWNISH CRYSTALLINE POWDER | | Uses | 1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents. | | Uses | - Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones
- Reactant for regioselective preparation of spirocyclic oxindole-butenolides
- Reactant for synthesis of spiro-oxindoles
- Reactant for preparation of unsymmetrical oxindoles
- Reactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction
- Reactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents
| | Synthesis Reference(s) | Journal of Medicinal Chemistry, 47, p. 2089, 2004 DOI: 10.1021/jm030483s | | General Description | The interaction between 1-methylisatin and human adult haemoglobin was studied using the circular dichroism (CD) spectroscopic, anisotropy and FTIR investigations. | | IC 50 | hiCE: 38.2 μM (Ki); hCE1: 5.38 μM (Ki) |
| | N-METHYLISATIN Preparation Products And Raw materials |
| Raw materials | 2-Butynamide, N-methyl-N-phenyl--->2-Propynamide, N-methyl-N-phenyl--->2-Propenamide,N-methyl-N,3-diphenyl--->Acetamide, N-methyl-2-(methylphenylamino)--->2-Propynamide, N-methyl-N,3-diphenyl--->1-Methylindoline-->4-Acetylbenzoic acid-->1-METHYL-2-INDOLINONE-->Ethanone, 1-[2-(methylamino)phenyl]- (9CI)-->Isatin-->1-benzyl-5-iodoindoline-2,3-dione-->5-iodo-1-methylindoline-2,3-dione | | Preparation Products | 2-Thiophenecarboxylic acid-->5-METHYL-1,2,4-TRIAZINO[5,6-B]INDOLE-3-THIOL-->1-METHYL-1H-INDOLE-2,3-DIONE 3-[N-(4-CHLOROPHENYL)HYDRAZONE]-->(7Z)-3-(4-fluorophenyl)-7-(1-methyl-2-oxoindol-3-ylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one |
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