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| | 5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) Basic information |
| | 5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) Chemical Properties |
| solubility | Formic Acid: 1 mg/ml |
| | 5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) Usage And Synthesis |
| Description | 5-FAM-Amyloid-β (1-28) peptide is a fluorescently labeled peptide. Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42.1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4 5-FAM-Amyloid-β (1-28) is a labeled form of Aβ28 containing 5-carboxyfluorescein (5-FAM; Item No. 19581), which displays excitation/emission maxima of 492/518 nm, respectively.WARNING This product is not for human or veterinary use. | | References | [1] CHRISTOPHER D SYME. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer’s disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques.[J]. The Journal of Biological Chemistry, 2004, 279 18: 18169-18177. DOI: 10.1074/jbc.m313572200
[2] D A KIRSCHNER. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 19: 6953-6957. DOI: 10.1073/pnas.84.19.6953
[3] D BURDICK. Assembly and aggregation properties of synthetic Alzheimer’s A4/beta amyloid peptide analogs.[J]. The Journal of Biological Chemistry, 1992, 267 1: 546-554.
[4] X A ALVAREZ. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats.[J]. Methods and findings in experimental and clinical pharmacology, 1997, 19 7: 471-479.
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| | 5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) Preparation Products And Raw materials |
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