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| | Acerinol Basic information |
| Product Name: | Acerinol | | Synonyms: | Acerinol;3,15a:8a,11-Diepoxybenzo[4',5']cyclohept[1',2':4,5]indeno[2,1-b]oxepin-2-methanol, 2,3,4,5,5a,5b,6,7,8,9,10,11,12,12a,13,14,14b,15-octadecahydro-15-hydroxy-α,α,5,5b,12,12,14b-heptamethyl-, (2S,3R,5R,5aR,5bR,8aS,11S,12aS,14bR,15R,15aS)- | | CAS: | 19902-53-5 | | MF: | C30H46O5 | | MW: | 486.69 | | EINECS: | | | Product Categories: | | | Mol File: | 19902-53-5.mol |  |
| | Acerinol Chemical Properties |
| Boiling point | 605.5±55.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | pka | 14.34±0.29(Predicted) |
| | Acerinol Usage And Synthesis |
| Description | Acerinol is a an active ingredient from traditional Chinese medicinal herbs that could be used as a cancer multidrug resistance reversal agent. Specifically, acerinol has been implicated in reversing resistance to the drugs that cause overexpression of the ABCB1 family of ATP-binding cassettes. Acerinol could increase the chemosensitivity of ABCB1-overexpressing HepG2/ADM and MCF-7/ADR cells to chemotherapeutic drugs, doxorubicin, vincristine and paclitaxel. Acerinol can significantly stimulate the activity of ABCB1 ATPase without affecting the expression of ABCB1 on neither mRNA nor protein level. Acerinol from C. acerina significantly enhances the cytotoxicity of chemotherapeutic drugs by modulating the function of ABCB1. | | Uses | Acerinol is a triterpenoid product that can be isolated from Cimicifuga acerina[1]. | | Definition | ChEBI: (1S,2R,3R,7S,12S,17R,18R,19R,22S)-22-(2-Hydroxypropan-2-yl)-3,8,8,17,19-pentamethyl-23,24,25-trioxaheptacyclo[19.2.1.19,12.01,18.03,17.04,14.07,12]pentacos-4(14)-en-2-ol is a sesquiterpenoid. |
| | Acerinol Preparation Products And Raw materials |
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