BMS-192364

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BMS-192364 Suppliers list
Company Name: BOC Sciences  
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354;
Email: support@targetmol.com
BMS-192364 Basic information
Product Name:BMS-192364
Synonyms:BMS-192364;3H-1,2,4-Triazol-3-one, 2-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-5-[4-(trifluoromethyl)phenyl]-;UNII-1NC8D8P7QF
CAS:202822-21-7
MF:C15H9ClF3N3O2
MW:355.7
EINECS:
Product Categories:
Mol File:202822-21-7.mol
BMS-192364 Structure
BMS-192364 Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
BMS-192364 Usage And Synthesis
UsesBMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux[1][2][3].
References[1] Kevin Fitzgerald, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57. DOI:10.1371/journal.pgen.0020057
[2] Maciej Salaga, et al. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016 Apr;38(4):344-54. DOI:10.1002/bies.201500118
[3] David P Basile, et al. A GAP in our knowledge of vascular signaling in acute kidney injury. Kidney Int. 2011 Aug;80(3):233-5. DOI:10.1038/ki.2011.145
BMS-192364 Preparation Products And Raw materials
Tag:BMS-192364(202822-21-7) Related Product Information
2-(2-Chloro-4-(trifluoromethyl)phenyl)-5-(2-chlorophenyl)-1H-1,2,4-triazol-3(2H)-one 3H-1,2,4-Triazol-3-one, 2-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-5-[2-(trifluoromethyl)phenyl]- 2-(4-Chlorophenyl)-1,2-dihydro-5-phenyl-3H-1,2,4-triazol-3-one 2-(2-Chloro-6-fluoro-4-(trifluoromethyl)phenyl)-5-phenyl-1H-1,2,4-triazol-3(2H)-one 2-(2-Chloro-4-(trifluoromethyl)phenyl)-5-(3,4-dichlorophenyl)-1H-1,2,4-triazol-3(2H)-one 5-(4-Chlorophenyl)-1,2-dihydro-2-phenyl-3H-1,2,4-triazol-3-one