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| | Secalonic acid D from penicillium*oxalicum Basic information |
| Product Name: | Secalonic acid D from penicillium*oxalicum | | Synonyms: | 1,1’,4,4’,8,8’-hexahydroxy-3,3’-dimethyl-9,9’-dioxo-,dimethylester,(3s-(3-a;7’-bi-4ah-xanthene)-4a,4’a-dicarboxylicacid,2,2’,3,3’,4,4’,9,9’-octahydro-(;ergochromeaa(2,2’)-5-beta,6-alpha,10-beta-5’,6’-alpha,10’-beta;lpha,4-beta,4a-beta,7(3’r,4’s,4’as)));[7,7'-Bi-4aH-xanthene]-4a,4'a-dicarboxylic acid, 2,2',3,3',4,4',9,9'-octahydro-1,1',4,4',8,8'-hexahydroxy-3,3'-dimethyl-9,9'-dioxo-, 4a,4'a-dimethyl ester, (3S,3'S,4R,4'R,4aR,4'aR)-;sad;secalonicacidd;Secalonic acid D from penicillium*oxalicum | | CAS: | 35287-69-5 | | MF: | C32H30O14 | | MW: | 638.57 | | EINECS: | | | Product Categories: | | | Mol File: | 35287-69-5.mol |  |
| | Secalonic acid D from penicillium*oxalicum Chemical Properties |
| Melting point | 257°C | | Boiling point | 591.32°C (rough estimate) | | density | 1.3167 (rough estimate) | | refractive index | 1.6130 (estimate) | | storage temp. | 2-8°C | | pka | 4.199±1.00(predicted) |
| Hazard Codes | T+ | | Risk Statements | 28 | | Safety Statements | 28-36/37-45 | | RIDADR | UN 2811 6.1/PG 2 | | RTECS | EC2460000 |
| | Secalonic acid D from penicillium*oxalicum Usage And Synthesis |
| Uses | Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis[1][2]. | | Definition | ChEBI: Secalonic acid D is a member of xanthenes. | | References | [1] Andersen R, et al. Secalonic acids D and F are toxic metabolites of Aspergillus aculeatus. J Org Chem. 1977 Jan 21;42(2):352-3. DOI:10.1021/jo00422a042
[2] Zhang JY, et al. Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G(1) with involvement of GSK-3beta/beta-catenin/c-Myc pathway. Cell Cycle. 2009 Aug;8(15):2444-50. DOI:10.4161/cc.8.15.9170 |
| | Secalonic acid D from penicillium*oxalicum Preparation Products And Raw materials |
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