Taurohyodeoxycholic acid sodium salt hydrate manufacturers
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| | Taurohyodeoxycholic acid sodium salt hydrate Basic information |
| Product Name: | Taurohyodeoxycholic acid sodium salt hydrate | | Synonyms: | Taurohyodeoxycholic acid sodium salt hydrate;Taurohyodeoxycholic acid hydrate sodium salt;Sodium taurohyodeoxycholate hydrate,Taurohyodeoxycholic acid sodium salt hydrate;5β-CHOLANIC ACID-3α, 6α-DIOL N-(2-SULPHOETHYL)-AMIDE;Taurine pig deoxycholate sodium;Taurohyodeoxycholic acid sodium salt, 10 mM in DMSO;Sodium taurocholic acid deoxycholate | | CAS: | 38411-85-7 | | MF: | C26H46NNaO6S | | MW: | 523.7 | | EINECS: | | | Product Categories: | | | Mol File: | 38411-85-7.mol |  |
| | Taurohyodeoxycholic acid sodium salt hydrate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | Taurohyodeoxycholic acid sodium salt hydrate Usage And Synthesis |
| Description | Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid . THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats. Co-administration of THDCA with taurochenodeoxycholic acid (TCDCA; ) prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats. THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis. | | Uses | Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions. | | General Description | Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent. | | References | [1] M ANGELICO. Dissolution of human cholesterol gallstones in bile salt/lecithin mixtures: effect of bile salt hydrophobicity and various pHs.[J]. Scandinavian Journal of Gastroenterology, 1995, 30 12: 1178-1185. DOI: 10.3109/00365529509101628
[2] M ANGELICO. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.[J]. Digestive Diseases and Sciences, 1994, 39 11: 2389-2397. DOI: 10.1007/bf02087656
[3] ALDO RODA. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid–induced cholestasis in the rat[J]. Hepatology, 2003, 27 2: 520-525. DOI: 10.1002/hep.510270228
[4] JIAO HE . Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice[J]. European journal of pharmacology, 2011, 670 1: Pages 229-235. DOI: 10.1016/j.ejphar.2011.08.036 |
| | Taurohyodeoxycholic acid sodium salt hydrate Preparation Products And Raw materials |
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Tag:Taurohyodeoxycholic acid sodium salt hydrate(38411-85-7)
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