Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]-

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Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]- Suppliers list
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
Products Intro: Product Name:VU0631019
CAS:1235656-95-7
Package:50mg/RMB 13800
Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]- Basic information
Product Name:Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]-
Synonyms:Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]-;VU0631019
CAS:1235656-95-7
MF:C20H26ClN3O2
MW:375.89
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Mol File:1235656-95-7.mol
Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]- Structure
Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]- Chemical Properties
Boiling point 471.0±45.0 °C(Predicted)
density 1.210±0.06 g/cm3(Predicted)
pka13.58±0.46(Predicted)
Safety Information
MSDS Information
Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]- Usage And Synthesis
UsesVU0631019 is a potent antagonist of 5-HT2B, with the IC50 of 29 nM. VU0631019 is predicted to have very limited potential for brain penetration in human subjects, as is predicted to be substrates for P-gp-mediated efflux in humans[1].
IC 505-HT2B Receptor: 29 nM (IC50)
References[1] Aaron M Bender, et al. Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen. Assay Drug Dev Technol. 2023 Apr;21(3):89-96. DOI:10.1089/adt.2022.116
Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]- Preparation Products And Raw materials
Tag:Urea, N-(2-chlorophenyl)-N'-[[1-[(2,5-dimethyl-3-furanyl)methyl]-4-piperidinyl]methyl]-(1235656-95-7) Related Product Information