| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
BSc5371 manufacturers
- BSc5371
-
- $1980.00
-
2026-07-27
- CAS:2286419-03-0
- Purity:
- Supply Ability: 10g
- BSc5371
-
- $1980.00
-
2026-07-27
- CAS:2286419-03-0
- Purity:
- Supply Ability: 10g
- BSc5371
-
- $1980.00
-
2025-08-22
- CAS:2286419-03-0
- Purity:
- Supply Ability: 10g
|
| | BSc5371 Basic information |
| Product Name: | BSc5371 | | Synonyms: | BSc5371;BSc-5371,BSc5371;1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-[5-[(ethenylsulfonyl)amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl- | | CAS: | 2286419-03-0 | | MF: | C24H31N5O4S | | MW: | 485.6 | | EINECS: | | | Product Categories: | | | Mol File: | 2286419-03-0.mol |  |
| | BSc5371 Chemical Properties |
| density | 1.305±0.06 g/cm3(Predicted) | | pka | 8.15±0.20(Predicted) |
| | BSc5371 Usage And Synthesis |
| Uses | BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines[1]. | | References | [1] Bensinger D, et al. Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. J Med Chem. 2019 Mar 14;62(5):2428-2446. DOI:10.1021/acs.jmedchem.8b01714 |
| | BSc5371 Preparation Products And Raw materials |
|