| Company Name: |
Novus Biologicals
|
| Tel: |
400821347 |
| Email: |
orders@novusbio.com |
| Products Intro: |
Product Name:GOT2 Antibody
|
| Company Name: |
CUSABIO TECHNOLOGY LLC
|
| Tel: |
027-87196173 |
| Email: |
cusabio@163.com |
| Products Intro: |
Product Name:GOT2 Antibody
|
| Company Name: |
Hubei Serenity BioSolutions Co., Ltd.
|
| Tel: |
027-19371278702 18008634902 |
| Email: |
19384116026@163.com |
| Products Intro: |
Product Name:Rabbit Polyclonal GOT2 Antibody
Package:20μl;50μl;100μl
|
| Company Name: |
GeneTex, Inc.
|
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Products Intro: |
Product Name:GOT2 antibody
|
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| | GOT2 antibody Chemical Properties |
| | GOT2 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | Glutamate oxaloacetate transaminase 2, a mitochondrial enzyme, catalyzes the conversion of oxaloacetate to aspartate. Studies show that the metabolite pyridoxal phosphate is selectively required by acute myeloid leukemia. PLP-dependent GOT2 selectively sustains leukemic cell proliferation. Depletion of GOT2 suppresses the proliferation of acute myeloid leukemia cells. In addition, mouse hematopoietic stem cells are dependent on cell-autonomous aspartate synthesis. Got2 deletion leads to decreased aspartate levels and reduced hematopoietic stem cell function. Furthermore, GOT2-dependent aspartate synthesis is also necessary for protein and collagen biosynthesis in chondrocytes and is critical for chondrocyte proliferation and growth. | | References | [1] Chen, C.C. et al. (2020) Cancer Cell 37, 71-84.e7.
[2] Qi, L. et al. (2021) Cell Stem Cell 28, 1982-1999.e8.
[3] Stegen, S. et al. (2020) Dev Cell 53, 530-544.e8. |
| | GOT2 antibody Preparation Products And Raw materials |
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