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| | Phospho-Cofilin (Ser3) (77G2) Rabbit mAb Chemical Properties |
| | Phospho-Cofilin (Ser3) (77G2) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey;Bovine | | Background | Cofilin and actin-depolymerization factor are members of a family of essential conserved small actin-binding proteins that play pivotal roles in cytokinesis, endocytosis, embryonic development, stress response, and tissue regeneration. In response to stimuli, cofilin promotes the regeneration of actin filaments by severing preexisting filaments. The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at Ser3 of cofilin. Phosphorylation at Ser3 also regulates cofilin translocation from the nucleus to the cytoplasm. | | References | [1] Carlier, M.F. et al. (1999) J Biol Chem 274, 33827-30.
[2] Condeelis, J. (2001) Trends Cell Biol 11, 288-93.
[3] Arber, S. et al. (1998) Nature 393, 805-9.
[4] Yang, N. et al. (1998) Nature 393, 809-12.
[5] Toshima, J. et al. (2001) J Biol Chem 276, 31449-58.
[6] Nebl, G. et al. (1996) J Biol Chem 271, 26276-80. |
| | Phospho-Cofilin (Ser3) (77G2) Rabbit mAb Preparation Products And Raw materials |
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