|
|
| | MYCi975 Basic information |
| Product Name: | MYCi975 | | Synonyms: | MYCi975;NUCC-0200975;[1,1'-Biphenyl]-2-ol, 4'-chloro-6-[(4-chlorophenyl)methoxy]-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3'-(trifluoromethyl)-;MYCi975 (NUCC-0200975);MYCi-975,MYCi975;4'-Chloro-6-((4-chlorobenzyl)oxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3'-(trifluoromethyl)-[1,1'-biphenyl]-2-ol;4’-Chloro-6-[(4-chlorobenzyl)oxy]-3-[1-methyl-3-(trifluoromethyl)-5-pyrazolyl]-3’-(trifluoromethyl)-[1,1’-biphenyl]-2-ol;MYCi975, 10 mM in DMSO | | CAS: | 2289691-01-4 | | MF: | C25H16Cl2F6N2O2 | | MW: | 561.3 | | EINECS: | | | Product Categories: | | | Mol File: | 2289691-01-4.mol |  |
| | MYCi975 Chemical Properties |
| Boiling point | 566.5±50.0 °C(Predicted) | | density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO:56.0(Max Conc. mg/mL);99.8(Max Conc. mM) | | pka | 7.99±0.50(Predicted) |
| | MYCi975 Usage And Synthesis |
| Description | MYCi975 is an inhibitor of the protein-protein interaction between Myc and Myc-associated factor X (MAX).1 It binds to Myc (Kd = 2.75 µM) and increases GSK3β-mediated Myc phosphorylation in a cell-free assay. MYCi975 (5 and 10 µM) decreases the viability of MyC-CaP and LNCaP prostate cancer cells. It induces apoptosis in a panel of 11 breast cancer cell lines when used at a concentration of 10 µM.2 In vivo, MYCi975 (100 mg/kg) reduces tumor volume in a MyC-CaP mouse xenograft model.WARNING This product is not for human or veterinary use. |
| | MYCi975 Preparation Products And Raw materials |
|