SPOP-IN-6b
| 中文名称 | SPOP-IN-6b |
|---|---|
| 中文同义词 | 化合物 T16922;化合物SPOP-IN-6B;化合物SPOP-IN-6B,10 MM DMSO 溶液;2-亚氨基-10-甲基-N-(3-吗啉丙基)-5-氧代-1-苯乙基-1,5-二氢-2H-二吡啶并[1,2-a:2',3'-d]嘧啶-3-甲酰胺 |
| 英文名称 | SPOP-IN-6b |
| 英文同义词 | SPOP-IN-6b;2H-Dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, 1,5-dihydro-2-imino-10-methyl-N-[3-(4-morpholinyl)propyl]-5-oxo-1-(2-phenylethyl)-;2-Imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide;SPOP-IN-6b, 10 mM in DMSO;6-imino-11-methyl-N-[3-(morpholin-4-yl)propyl]-2-oxo-7-(2-phenylethyl)-1,7,9-triazatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,9,11,13-pentaene-5-carboxamide - [AC78124] |
| CAS号 | 2136270-20-5 |
| 分子式 | C28H32N6O3 |
| 分子量 | 500.59 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2136270-20-5.mol |
| 结构式 |  |
SPOP-IN-6b 性质
| 密度 | 1.32±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：10 mg/mL（19.98 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.90±0.20(Predicted) |
| 颜色 | 浅黄至黄色 |
SPOP-IN-6b 是一种 SPOP 抑制剂，来自专利 CN 107141287，化合物 SPOP-B-88。
SPOP
SPOP-IN-6b a SPOP inhibitor with an IC
50
of 3.58 μM in cell assay.
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content.
SPOP-IN-6b suppresses intracellular SPOP acted on substrate PTEN ubiquitination.
Cell Viability Assay
| Cell Line: | A498 cells |
| Concentration: | 0.1 μM, 0.3 μM, 1.0 μM, 3.0 μM |
| Incubation Time: | 10 hours |
| Result: | Suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content. |
SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP.
| Animal Model: | Nude mice |
| Dosage: | 40 mg/kg, 60 mg/kg, 80 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 25 days |
| Result: | Slowed down the growth of tumour by suppressing SPOP. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-122615 | SPOP-IN-6b | 2136270-20-5 | 1 mg | 1100元 |
| 2025/12/22 | HY-122615 | SPOP-IN-6b SPOP-IN-6b | 2136270-20-5 | 5mg | 2200元 |