|
|
| | 6,15-Eicosadienoic acid, 20-hydroxy-, (6Z,15Z)- Basic information |
| Product Name: | 6,15-Eicosadienoic acid, 20-hydroxy-, (6Z,15Z)- | | Synonyms: | 6,15-Eicosadienoic acid, 20-hydroxy-, (6Z,15Z)-;WIT 002;20 HEDE,20HEDE;(6Z,15Z)-20-hydroxyicosa-6,15-dienoic acid;(6Z,15Z)-20-Hydroxy-6,15-eicosadienoic acid | | CAS: | 240427-90-1 | | MF: | C20H36O3 | | MW: | 324.5 | | EINECS: | | | Product Categories: | | | Mol File: | 240427-90-1.mol |  |
| | 6,15-Eicosadienoic acid, 20-hydroxy-, (6Z,15Z)- Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Liquid | | color | Off-white to yellow |
| | 6,15-Eicosadienoic acid, 20-hydroxy-, (6Z,15Z)- Usage And Synthesis |
| Uses | 20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE). | | Definition | ChEBI: 20-HeDE is a long-chain fatty acid. | | in vivo | The effect of the 20-HETE antagonist, WIT 002 on the growth of 786-O clear cell renal carcinoma is assessed in ectopic mouse model of renal tumor. The growth of tumors is significantly suppressed by WIT 002 administered daily to athymic nude mice implanted subcutaneously with cells 786-O. Tumor growth is inhibited by 84%±128%. It is of note that in these experiments WIT 002 treatment start only after the tumor is seeded for 7-14 days and is relatively large 0.1 cm. Thus, WIT 002 is effective at arresting the growth of a fairly advanced tumor[3]. | | References | [1] Ming Yua . et al. Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol. 2004 Feb 23;486(3):297-306. DOI:10.1016/j.ejphar.2004.01.009
[2] Wei Yu, et al. Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol. 2011 Sep; 68(3): 619-29. DOI:10.1007/s00280-010-1521-8
[3] Anna Alexanian, et al. Down-regulation of 20-HETE Synthesis and Signaling Inhibits Renal Adenocarcinoma Cell Proliferation and Tumor Growth. Anticancer Res. 2009 October ; 29(10): 3819-3824. PMID:19846914 |
| | 6,15-Eicosadienoic acid, 20-hydroxy-, (6Z,15Z)- Preparation Products And Raw materials |
|