| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
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| | SCF Extracellular Domain (human, recombinant) Basic information |
| | SCF Extracellular Domain (human, recombinant) Chemical Properties |
| | SCF Extracellular Domain (human, recombinant) Usage And Synthesis |
| Description | Stem cell factor (SCF), also known as steel factor or c-Kit ligand, is a growth factor and cytokine that promotes proliferation, migration, survival, and differentiation of hematopoietic progenitors, germ cells, and melanocytes and is encoded by KITLG in humans.1 It is composed of an extracellular domain that contains a c-Kit binding region, a transmembrane domain, and a C-terminal intracellular tail and is ubiquitously expressed by fibroblasts and endothelial cells. SCF also exists as a soluble form produced by proteolytic cleavage of a membrane-bound isoform of SCF produced by alternative splicing and lacking exon 6. Both membrane-bound and soluble SCF homodimerize and bind to the SCF receptor, also known as c-Kit, to induce intracellular signaling. Allergen exposure increases lung and serum levels of SCF in a mouse model of allergic inflammation, and airway levels of SCF are increased in patients with asthma.2 Exogenous administration of SGF decreases infarct size and improves motor function in a spontaneously hypertensive rat model of stroke induced by middle cerebral artery occlusion.3 SCF inhibits apoptosis of CD34+ acute myeloid leukemia cells induced by cytarabine (Item No. 16069), daunorubicin (Item No. 14159), or carboplatin (Item No. 13112).4 Cayman's SCF Extracellular Domain (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 175 amino acids, has a calculated molecular weight of 19.9 kDa, and a predicted N-terminus of Glu26 after signal peptide cleavage.WARNING This product is not for human or veterinary use. |
| | SCF Extracellular Domain (human, recombinant) Preparation Products And Raw materials |
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