PIPERAZINE-2-CARBOXYLIC ACID manufacturers
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| | PIPERAZINE-2-CARBOXYLIC ACID Basic information | | Application |
| Product Name: | PIPERAZINE-2-CARBOXYLIC ACID | | Synonyms: | (+/-)-PIPERAZINE-2-CARBOXYLIC ACID HYDROCHLORIDE;R,S-PIPERAZINE-2-CARBOXYLIC ACID;TIMTEC-BB SBB004226;2-PIPERAZINECARBOXYLIC ACID;(S)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE 98%;Piperazine-2-carboxylicacidHCl;2-piperazinecarboxyli acid;piperazin-2-carboxylic acid | | CAS: | 133525-05-0 | | MF: | C5H10N2O2.2ClH | | MW: | 203.07 | | EINECS: | | | Product Categories: | | | Mol File: | 133525-05-0.mol |  |
| | PIPERAZINE-2-CARBOXYLIC ACID Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant |
| | PIPERAZINE-2-CARBOXYLIC ACID Usage And Synthesis |
| Application | Piperazine-2-carboxylic acid dihydrochloride can be used as a pharmaceutical synthesis intermediate. The reaction proceeds as follows: Piperazine-2-carboxylic acid dihydrochloride (2 g, 9.8 mmol) and (Boc)₂O (8.6 g, 39.4 mmol) are dissolved in THF (40 mL) and water (40 mL). Sodium bicarbonate (8.31 g, 79.8 mmol) is added. The reaction mixture is magnetically stirred at room temperature for 4 hours, then ethyl acetate is added. The mixture is separated using a separatory funnel. The separated organic phase is washed with saturated brine, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and then separated by silica gel column chromatography. 2.5 g of 1,4-di-tert-butoxycarbonylpiperazine-2-carboxylic acid (13-2) was obtained after purification, with a yield of 78%. LC-MS (ESI): m/z (M+1) 331.2. |
| | PIPERAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
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