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| | 2-Chloro-3-fluoro-5-methylpyridine Basic information |
| Product Name: | 2-Chloro-3-fluoro-5-methylpyridine | | Synonyms: | 2-CHLORO-3-FLUORO-5-METHYLPYRIDINE;2-CHLORO-3-FLUORO-5-PICOLINE;6-Chloro-5-fluoro-3-picoline;2-Chloro-3-fluoro-5-picoline
2-Chloro-3-fluoro-5-methylpyridine;Pyridine, 2-chloro-3-fluoro-5-methyl-;2-Chloro-3-fluoro-5-methylpyridine,95%;2-Chloro-3-fluoro-5-methylpyridine ISO 9001：2015 REACH | | CAS: | 34552-15-3 | | MF: | C6H5ClFN | | MW: | 145.56 | | EINECS: | | | Product Categories: | Fluorine series;Pyridine;Pyridines | | Mol File: | 34552-15-3.mol |  |
| | 2-Chloro-3-fluoro-5-methylpyridine Chemical Properties |
| Melting point | 29-30 °C | | Boiling point | 92°C/25mmHg(lit.) | | density | 1.264±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | soluble in Methanol | | pka | 0.35±0.10(Predicted) | | form | Solid | | color | White | | CAS DataBase Reference | 34552-15-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 2-Chloro-3-fluoro-5-methylpyridine Usage And Synthesis |
| Synthesis | Example 11 Preparation of 2-chloro-3-fluoro-5-methylpyridine: 1.92 g of 2-fluoro-4-chloro-4-formylpentanenitrile (CAS: 99268-30-1) was placed in a 50 mL Carius tube and 10 mL of acetonitrile was added as a solvent. Dry HCl gas was passed into the reaction system for 10 seconds. Subsequently, the reaction mixture was heated at 180°C for 20 min. After completion of the reaction, the acetonitrile solvent was evaporated under reduced pressure. The residue was dissolved in 5 mL of dichloromethane and purified by silica gel column chromatography (230-400 mesh, 4 cm × 20 cm). The first fraction containing the target product 2-chloro-3-fluoro-5-methylpyridine was collected. The solvent was removed under vacuum to give 700 mg of product in 44% yield. The product was characterized by the following data: 1H NMR (acetone-d6) δ 2.35 (s, 3H, -CH3), 7.50 (dd, 1H, pyr-H4), 8.07 (wide s, 1H, pyr-H6); IR (NaCl, neat) 1450 cm-1, 1408 cm-1, 1215 cm-1, 1085 cm-1, 880 cm -1, 720 cm-1, 711 cm-1; CIMS (CM4) MH+ m/e 146 (100%), MH++2 m/e 148 (35%). | | References | [1] Journal of Organic Chemistry, 1985, vol. 50, # 25, p. 5115 - 5119
[2] Patent: US4562009, 1985, A |
| | 2-Chloro-3-fluoro-5-methylpyridine Preparation Products And Raw materials |
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