4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers
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| | 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Basic information |
| Product Name: | 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER | | Synonyms: | 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;ETHYL 4-HYDROXY-8-METHOXY-3-QUINOLINECARBOXYLATE;ETHYL 4-HYDROXY-8-METHOXYQUINOLINE-3-CARBOXYLATE;BUTTPARK 20\09-65;2-ethyl-8-methoxy-4-oxo-1H-quinoline-3-carboxylate;Ethyl 1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate;Ethyl 8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate;4-keto-8-methoxy-1H-quinoline-3-carboxylic acid ethyl ester | | CAS: | 27568-04-3 | | MF: | C13H13NO4 | | MW: | 247.25 | | EINECS: | 803-472-3 | | Product Categories: | blocks;Carboxes;Quinolines;pharmacetical | | Mol File: | 27568-04-3.mol |  |
| | 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties |
| Boiling point | 373.2±37.0 °C(Predicted) | | density | 1.277 | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | 2.72±0.50(Predicted) | | Appearance | Light yellow to brown Solid |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26-24/25 | | WGK Germany | 3 | | HS Code | 29334900 |
| | 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Usage And Synthesis |
| Chemical Properties | Off-white solid | | Synthesis | Step B: Synthesis of ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate: Diethyl 2-(((2-methoxyphenyl)amino)methylene)malonate (47.6 g, 162 mmol) was suspended in Dowtherm (100 mL) and heated to 250 °C. The reaction mixture was kept in a sand bath overnight, subsequently cooled to room temperature and diluted with pentane (750 mL). The resulting solid product was collected by filtration and washed with hexane to afford the target compound (25.7 g, 64% yield). Mass spectrometry analysis (APCI) showed m/z 248.0 ([M + H]+). | | References | [1] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 66 |
| | 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials |
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