| Company Name: |
Biolab Reagents |
| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
| Company Name: |
ACROBiosystems |
| Tel: |
13121935750 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
|
| | FAS LIGAND Basic information |
| | FAS LIGAND Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | biological source | rabbit |
| Safety Statements | 22-24/25 | | WGK Germany | WGK 3 | | Storage Class | 10 - Combustible liquids |
| | FAS LIGAND Usage And Synthesis |
| Uses | Fas Ligand (FASLG) from mouse has been used for-
- the induction of apoptosis in PC12 cells and
- the induction of migration in BV-2 murine microglial cells.
| | Biological Activity | FASLG (Fas ligand) and Fas receptor constitute the basic elements in apoptosis. Interaction of FASLG with Fas receptor leads to activation of caspase-8. This caspase in turn leads to activation of effector caspases such as caspase-3, -6 and -7. This cascade results in the hydrolysis of nuclear and cytoplasmic components. Expression of FASLG is induced by nuclear factor-KB (NFKB). NFKB/FASLG pathway facilitates the suppression of p,pμ-DDT (dichlorodiphenoxytrichloroethane)-induced cell toxicity by vitamin C and E. In CD4+ T cells, this protein is expressed on stimulus by T-cell receptor (TCR), both during normal and pathological conditions, such as alcohol exposure.', 'Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1). |
| | FAS LIGAND Preparation Products And Raw materials |
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