- 5-Nitroindazole
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-
2026-06-25
- CAS:5401-94-5
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 2500kg/month
- 5-Nitroindazole
-
-
2025-04-04
- CAS:5401-94-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
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| | 5-Nitroindazole Basic information |
| | 5-Nitroindazole Chemical Properties |
| Melting point | 207 °C | | Boiling point | 383.3±15.0 °C(Predicted) | | density | 1.525±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 11.71±0.40(Predicted) | | form | powder to crystal | | color | White to Light red to Green | | BRN | 7936 | | InChI | InChI=1S/C7H5N3O2/c11-10(12)6-1-2-7-5(3-6)4-8-9-7/h1-4H,(H,8,9) | | InChIKey | WSGURAYTCUVDQL-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C([N+]([O-])=O)C=C2)C=N1 | | CAS DataBase Reference | 5401-94-5(CAS DataBase Reference) | | EPA Substance Registry System | 5-Nitroindazole (5401-94-5) |
| | 5-Nitroindazole Usage And Synthesis |
| Chemical Properties | light yellow crystal | | Uses | 5-Nitroindazole inhibits citrulline formation by Ca2+-calmodulin (CaM)-dependent nitric oxide synthase from bovine brain. Nitration of 5-nitroindazole with nitric acid and acetic anhydride yields 3,5-dintroindazole and 2,5-dinitroindazole. | | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 21, p. 1063, 1984 DOI: 10.1002/jhet.5570210428
Organic Syntheses, Coll. Vol. 3, p. 660, 1955 | | Synthesis | General procedure: hydrazine hydrate (NH2NH2-H2O, 3.0 mmol) was added dropwise to a stirred solution of 2-fluoro-5-nitrobenzaldehyde (1.0 mmol) in DMF (5 mL) at 23 °C. The reaction mixture was stirred continuously at the same temperature for 2 h. The progress of the reaction was monitored by thin-layer chromatography (TLC, unfolding agent: 20% ethyl acetate in hexane solution) to confirm the complete conversion of the starting material 2-fluoro-5-nitrobenzaldehyde. Upon completion of the reaction, the crude reaction mixture was poured into water and extracted with ethyl acetate (2 x 15 mL). The organic phases were combined, washed sequentially with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give pure 5-nitroindazole. | | References | [1] Molecules, 2018, vol. 23, # 3,
[2] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569 |
| | 5-Nitroindazole Preparation Products And Raw materials |
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