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| | 2-FLUORO-5-NITROPHENYLACETIC ACID Basic information |
| Product Name: | 2-FLUORO-5-NITROPHENYLACETIC ACID | | Synonyms: | 2-FLUORO-5-NITROPHENYLACETIC ACID;3-(Carboxymethyl)-4-fluoronitrobenzene;2-fluoro-5-nitrophenyl acetate;2-FLUORO-5-NITROPHENYLACETIC;2-(2-Fluoro-5-nitrophenyl)acetic acid;Benzeneacetic acid, 2-fluoro-5-nitro-;2-(2-fluoro-5-nitrophenyl)aceticaci;2-FLUORO-5-NITROPHENYLACETIC ACID ISO 9001：2015 REACH | | CAS: | 195609-18-8 | | MF: | C8H6FNO4 | | MW: | 199.14 | | EINECS: | 242-641-0 | | Product Categories: | Phenylacetic acid | | Mol File: | 195609-18-8.mol |  |
| | 2-FLUORO-5-NITROPHENYLACETIC ACID Chemical Properties |
| Melting point | 149-150 | | Boiling point | 375.5±27.0 °C(Predicted) | | density | 1.498 | | storage temp. | Store at room temperature | | pka | 3.76±0.10(Predicted) | | form | powder | | color | Off white to faint lemon |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | HazardClass | IRRITANT | | HS Code | 2916399090 |
| | 2-FLUORO-5-NITROPHENYLACETIC ACID Usage And Synthesis |
| Chemical Properties | Light yellow crystalline | | Uses | 2-Fluoro-5-nitrophenylacetic acid can be used to prepare thickened heterocyclic compounds as protein kinase inhibitors. | | Synthesis | General procedure for the synthesis of 2-fluoro-5-nitrophenylacetic acid from o-fluorophenylacetic acid: o-fluorobenzoic acid (30.0 g, 0.19 mol) was dissolved in a mixed solution of concentrated sulfuric acid (50 mL) and water (10 mL). A mixed solution of fuming nitric acid (10 mL) and water (10 mL) was added slowly and dropwise at 0 °C. The reaction mixture was kept stirred at 0 °C for 30 min. Upon completion of the reaction, the resulting precipitate was collected by filtration and washed with cold water. Finally, the product was dried under vacuum to afford 2-(2-fluoro-5-nitrophenyl)acetic acid as a white solid (35.2 g, 91% yield). | | References | [1] Patent: WO2010/91310, 2010, A1. Location in patent: Page/Page column 99
[2] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 15, p. 2229 - 2235
[3] Tetrahedron, 2000, vol. 56, # 50, p. 9809 - 9818
[4] Patent: US2006/30609, 2006, A1. Location in patent: Page/Page column 15 |
| | 2-FLUORO-5-NITROPHENYLACETIC ACID Preparation Products And Raw materials |
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