| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:Z-FA-FMK
CAS:105637-38-5
Purity:95%HPLC Package:116USD/5mg
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| Company Name: |
Shanghai Harvest Chemical Industrial Co., Ltd.
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| Tel: |
021-31038972,31038973 17321035817 |
| Email: |
sales@harvest-chem.com |
| Products Intro: |
Product Name:Z-FA-FMK
CAS:105637-38-5
Purity:98%min Package:10g;100g Remarks:From stock
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| | Z-FA-FMK Basic information |
| Product Name: | Z-FA-FMK | | Synonyms: | NEGATIVE CONTROL INHIBITOR FOR ICE PROTEASES;Z-FA-FLUOROMETHYLKETONE;Z-FA-FMK;Z-PHE-ALA-CH2F;Z-PHE-ALA-FLUOROMETHYLKETONE;Z-PHE-ALA-FMK;CASPASE INHIBITOR, NEGATIVE CONTROL;CATHEPSIN B, INHIBITOR | | CAS: | 105637-38-5 | | MF: | C21H23FN2O4 | | MW: | 386.42 | | EINECS: | | | Product Categories: | Caspase/Related Products;Inhibitor | | Mol File: | 105637-38-5.mol |  |
| | Z-FA-FMK Chemical Properties |
| Melting point | 125 - 127°C | | Boiling point | 630.5±55.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO or DMF: 20 mM | | form | powder | | pka | 11.07±0.46(Predicted) | | color | white to off-white | | InChI | 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27) | | InChIKey | ASXVEBPEZMSPHB-UHFFFAOYSA-N |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Z-FA-FMK Usage And Synthesis |
| Uses | Cell permeable negative control for FMK-labelled caspase inhibitors. Also an irreversible inhibitor of cathepsins B, L, and S | | Uses | Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain. | | Biological Activity | Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteases, such as cathepsin B and L. It can also inhibit recombinant effector caspases 2, -3, -6, and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor K-light-chain-enhancer of activated B cells (NF-KB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis. |
| | Z-FA-FMK Preparation Products And Raw materials |
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