- 2-Chloro-4-Iodobenzene
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- $200.00 / 1KG
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2025-09-25
- CAS:153034-86-7
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
- 2-Chloro-4-iodopyridine
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- $10.00 / 1kg
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2023-08-10
- CAS:153034-86-7
- Min. Order: 1kg
- Purity: 99.99%
- Supply Ability: 50000tons
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| | 2-Chloro-4-iodopyridine Basic information |
| | 2-Chloro-4-iodopyridine Chemical Properties |
| Melting point | 42-43 °C (lit.) | | Boiling point | 255.5±20.0 °C(Predicted) | | density | 2.052±0.06 g/cm3(Predicted) | | Fp | 110 °C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform, Ethyl Acetate | | form | Crystals or Crystalline Flakes | | pka | -0.03±0.10(Predicted) | | color | White to yellow | | Sensitive | Light Sensitive | | BRN | 108668 | | CAS DataBase Reference | 153034-86-7(CAS DataBase Reference) |
| | 2-Chloro-4-iodopyridine Usage And Synthesis |
| Chemical Properties | Off-white Cryst | | Uses | 2-Chloro-4-iodopyridine (cas# 153034-86-7) is a compound useful in organic synthesis. | | Synthesis | General procedure for the synthesis of 2-chloro-4-iodopyridine from 2-chloro-3-iodopyridine: 2-chloro-3-iodopyridine (12 g, 50 mmol) was prepared as a solution by dissolving it in 20 mL of tetrahydrofuran (THF). The solution was slowly added to a pre-prepared lithium diisopropylammonium solution at -78°C (the lithium diisopropylammonium solution was prepared by reacting 1.6 M n-butyllithium hexane solution (31.25 mL, 50 mmol) with diisopropylamine (7 mL, 50 mmol) in 100 mL THF). After 3 hours of reaction, the reaction was quenched by adding 20 mL of water to the reaction mixture, followed by extraction with ether (2 x 100 mL). The organic layers were combined, dried with magnesium sulfate, filtered and concentrated under vacuum at 20 °C to give a brown solid. Purification by silica gel column chromatography (eluent: ethyl acetate/heptane=8/2) gave light yellow needle-like crystals in 95% yield (11.4 g). The structure of the product was analyzed by 1H NMR (CDCl3): δ 8.07 (d, J = 5.3 Hz, 1H), 7.76 (d, J = 1.1 Hz, 1H), 7.59 (dd, J = 5.0/0.11 Hz, 1H); 13C NMR (CDCl3): δ 151.7, 149.6, 133.0, 131.5, 106.6; MS ( EI) m/z 240 (M + 1) confirmed. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1397 - 1401
[2] Patent: WO2004/52880, 2004, A1. Location in patent: Page 30
[3] Patent: US2009/186899, 2009, A1. Location in patent: Page/Page column 45-46
[4] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[5] Patent: US2008/249128, 2008, A1. Location in patent: Page/Page column 46 |
| | 2-Chloro-4-iodopyridine Preparation Products And Raw materials |
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